Aerosolized xylitol (5 ml) twice daily for 14 days

Aerosolized 7% hypertonic saline (4 ml) twice daily for 14 days

Baseline characteristics of the entire study cohort

All Participants

Sex: Female, Male

Region of Enrollment

FEV1

Change from baseline in FEV1(maximal amount of air you can forcefully exhale in one second) % predicted

Drug
Aerosolized xylitol (5 ml) twice daily for 14 days
Xylitol: Aerosolized 15% xylitol, 5 ml twice a day for 2 weeks, Xylo-pentane-1,2,3,4 5-pentol: 5 ml of 15 % aerosolized 2 times per day

Xylitol

Saline

Change in FEV1 % Predicted From Baseline

Difference from baseline in density of Pseudomonas aeruginosa colonization per gram of sputum,

Sputum Density

Drug
Xylitol: Aerosolized 15% xylitol, 5 ml twice a day for 14 days Xylo-pentane-1,2,3,4 5-pentol: 5 ml of 15 % aerosolized 2 times per day
Saline:
Hypersal: Hypertonic saline 7%, 4 ml twice a day for 14 days

Xylitol First Then Saline

Aerosolized 7% hypertonic saline (4 ml) twice daily for 14 days
Xylitol: Aerosolized 15% xylitol, 5 ml twice a day for 2 weeks
Xylo-pentane-1,2,3,4 5-pentol: 5 ml of 15 % aerosolized 2 times per day

Saline First and Then Xylitol

Overall Study

Janice Launspach

Drug
Aerosolized xylitol (5 ml) twice daily for 14 days
Xylitol: Aerosolized 15% xylitol, 5 ml twice a day for 2 weeks
Xylo-pentane-1,2,3,4 5-pentol: 5 ml of 15 % aerosolized 2 times per day

Aerosolized Hypertonic Xyltiol

Hypertonic Saline

Cystic Fibrosis

Aerosolized 15% xylitol, 5 ml twice a day for 2 weeks

4 ml of 7 % saline aerosolized twice a day for 2 weeks

Hypertonic saline

Northwestern University

Ann & Robert H. Lurie Children's Hospital of Chicago

Inhaled Xylitol Versus Saline in Stable Subjects With Cystic Fibrosis

Randomized Cross Over Study of Inhaled Hypertonic Xylitol Versus Hypertonic Saline in Stable Subjects With Cystic Fibrosis

Joseph Zabner

Professor

Ann & Robert H Lurie Children's Hospital of Chicago

ICG arm- will be defined as local application on a pledget soaked with ICG with a concentration of 200µg, upon removal of the pledget a NIR diode laser set at 6W with light emittance introduced intranasally with a 30mm diffuser fiber capable of radiating light circumferentially allowing the light energy to reach all treatable areas. Laser will be activated for 180 seconds. Assuming an approximate radius of the nasal cavity is 3mm, energy density will be around 200J/cm². Treatment will be repeated twice, 5-7 day apart. Cultures will be collected at the end of all treatments

Rhinosinusitis

Laser + ICG

Laser only

St.Luke's-Roosevelt, New York Head Neck Institute

Head Neck Surgical Group

New York Head Neck Institute

Laser Assisted Treatment of Chronic Sinusitis With and Without Light Activated Agents

Laser Microbial Killing With Photo Activated Agents

Yosef Krespi, Victor Kizhner

New York Head & Neck Institute

Valam Corp.

15% xylitol solution for aerosol; Dosage: 5 ml twice a day (BID)

7% hypertonic saline solution for aerosol; Dosage: 5 ml twice a day (BID)

University of Iowa Hospitals and Clinics

Aerosolized Hypertonic Xylitol Versus Hypertonic Saline in Cystic Fibrosis (CF) Subjects

Randomized Controlled Study of Aerosolized Hypertonic Xylitol Versus Hypertonic Saline in Hospitalized Patients With Exacerbation of Cystic Fibrosis

Blood, throat swab, nasopharyngeal aspiration, and rectal swab will be obtained during acute illness and at convalescence (about 2 weeks after discharge). These specimens will be processed for viral isolation, bacterial culture and toxin detection, PCR, subtractive cloning, VIDISCA, gene chips, peptide library, cytokine/chemokine measurement, antibody detection for specific pathogens, etc. Questionnaire for contact history and clinical symptoms will be performed.

Kawasaki Disease

National Taiwan University Hospital

Etiology Study of Kawasaki Disease

Etiology Study of Kawasaki Disease--A Prospective Household and Case Control Study

The mean age of the 226 KD cases was 2.07 years, and the male to female ratio was 1.43 (133 boys to 93 girls). Their mean fever duration was 7.5 days with a mean peak temperature of 39.7°C. In addition to the typical symptoms of fever, neck lymphadenopathy, lip fissure and/or strawberry tongue, skin rash, nonpurulent bulbar conjunctivitis, palm/sole erythema, and induration followed by periungual desquamation, these KD cases also exhibited cough (69%), rhinorrhea (58%), and diarrhea (45%). Cases of KD had a significantly higher positive rate of viral isolation in comparison with the control group (7.5% vs. 2.2%, p = 0.02). Compared with the control group, cases of KD were more likely to have overall positive rates of viral PCR (50.4% vs. 16.4%, p < 0.001) and for various viruses including enterovirus (16.8% vs. 4.4%, p < 0.001), adenovirus (8.0% vs. 1.8%, p = 0.007), human rhinovirus (26.5% vs. 9.7%, p < 0.001), and coronavirus (7.1% vs. 0.9%, p = 0.003).

coagulase/próchnica zębów

Inhaled Xylitol Versus Saline in Stable Subjects With Cystic Fibrosis

Laser Assisted Treatment of Chronic Sinusitis With and Without Light Activated Agents

Aerosolized Hypertonic Xylitol Versus Hypertonic Saline in Cystic Fibrosis (CF) Subjects

Etiology Study of Kawasaki Disease

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