Oral single dose of Combination of 1000mg acetaminophen- 16mg codeine- 60mg caffeine.

Oral single dose of 1000mg acetaminophen.

Symptomatic Irreversible Pulpitis

The patient will receive pretreatment oral single dose of Combination of 1000mg acetaminophen- 16mg codeine- 60mg caffeine 1 hour before treatment.

Acetaminophen and codeine and caffeine

The patient will receive pretreatment oral single dose of 1000mg acetaminophen alone 1 hour before treatment.

Acetaminophen

The patient will receive placebo (starch) 1hour before treatment.

Placebo

Preoperative Acetaminophen- Caffeine- Codeine Combination and Anaesthetic Success in Patients With Acute Pulpitis

Effect of Preoperative Acetaminophen-Codeine-Caffeine Combination on Inferior Alveolar Nerve Block Success in Patients With Symptomatic Irreversible Pulpitis: Randomized Double-blind Controlled Trial

Will be recorded by 11 point NRS consisting of numbers from 0 through 10. 0: reading represents "no pain" 1-3 : readings represent "mild pain" 4-6 : readings represent "moderate pain" 7-10 : readings represent "severe pain" 0: reading represents "no pain" 1-3 : readings represent "mild pain" 4-6 : readings represent "moderate pain" 7-10 : readings represent "severe pain"

Will be recorded by 11point NRS 0: reading represents "no pain" 1-3 : readings represent "mild pain" 4-6 : readings represent "moderate pain" 7-10 : readings represent "severe pain"

Alaa Mohammed Abdallah Morsi

Post graduate student, Department of Endodontics, Faculty of Dentistry,Cairo University

Cairo University

Patients undergoing third molar extraction with antibiotic treatment.
Amoxicillin 250 mg , three times daily for five days.

Patients undergoing third molar extraction with antibiotic treatment.

Age and sex matched controls who are not undergoing extractions or antibiotic treatment

Impacted Third Molar Tooth

Extraction

Oral Rehabilitation, Faculty of Dentistry, The University of Hong Kong

Impact of Antibiotic Treatment and Extraction on the Oral Micro Biome

The Impact of Amoxicillin Use on the Stability of the Oral Microbiome in Systemically Healthy Cohorts Undergoing Tooth Extractions - A Prospective Clinical Study

Dr Michael G. Botelho

Clinical Associate Professor

The University of Hong Kong

No randomization is performed. Patients who are prescribed antibiotics by the clinician performing the tooth extraction ( based on case complexity and intra operative judgement) are recruited into this group.The principal investigator is not involved in the decision to prescribe antibiotics or not.

Patients who do not receive antibiotics after extractions are recruited into this group.

Amoxicillin

Changes in Resistome After Dental Extraction and Amoxicillin.

Evaluation of the Changes in Oral and Gut Bacterial Resistance Caused by Short Term Antibiotic Treatment Following a Surgical Dental Procedure - A Prospective Clinical Study.

Resistome analysis Changes in the (relative) concentration of total resistance genes (the resistome) in the metagenomic DNA sequences will be analyzed as follows: Antibiotic resistance genes will be downloaded from the Antibiotic Resistance Genes Database (20). The downloaded dataset (ardbAnno1.0), containing 7828 entries, will be made non-redundant first and UBLAST from USEARCH v7.0.1090 (20) will be used to map the reads to the (ARDB) proteins (E-value threshold 10, post-filtered to include hits with a maximum E-value of 1E-10 inclusive).
The results will be processed with HUMAN (21) to assign weights to the proteins. These weights were then normalized by dividing by the total number of filtered (non-human) reads, and summarized per antibiotic resistance type in the resistome. Next, fold changes will calculated for all resistance types with a baseline weight larger than 1E-8.

Deidentified patient data will be published within 6 months of the study completion.

codeine/próchnica zębów

Preoperative Acetaminophen- Caffeine- Codeine Combination and Anaesthetic Success in Patients With Acute Pulpitis

Impact of Antibiotic Treatment and Extraction on the Oral Micro Biome

Changes in Resistome After Dental Extraction and Amoxicillin.

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