Patients will be randomised to treatment with Deferoxamine (n=87). Deferoxamine (0.66mg/ml) will be applied locally as a gel (3 times a week) for a period of maximum three months or until intact skin.

Patients will be randomised to treatment with placebo (n=87). Placebo will be applied locally as a gel (3 times a week) for a period of maximum three months or until intact skin.

Diabetic Foot Ulcer

Deferoxamine (0.66mg/ml) will be applied locally as a gel (3 times a week) for a period of maximum three months or until intact skin.

Deferoxamine

Placebo will be applied locally as a gel (3 times a week) for a period of maximum three months or until intact skin.

Placebo

Effect of Deferoxamine on Wound Healing Rate in Patients With Diabetes Foot Ulcers

number of patients who have intact skin healing

the number of patients who have ulcer healing improvement of > 50%

Sergiu Catrina

Associated professor

Karolinska University Hospital

prospective, randomised, double-blind and placebo-controlled study with parallel groups, multiple centre trial.

The drugs (active or placebo) will be supplied by the supervision of Medigelium AB and will have the same appearance.

Patients will be randomized (by block randomization) to Desferal (DFO) treatment.

Patients will be randomized (by block randomization) to isotonic saline treatment.

Diabetes Mellitus, Type 1

It is a blinded randomized cross-over study that investigates the efficacy of DFO (50mg/kg) given i.v before intermittent hypoxia (IH) to improve the cardiorespiratory and angiogenetic response in patients with diabetes.

desferal

It is a blinded randomized cross-over study that investigates the efficacy of isotonic saline given i.v before intermittent hypoxia (IH) to improve the cardiorespiratory and angiogenetic response in patients with diabetes.

Isotonic saline

Desferal Administration to Improve the Impaired Reaction to Hypoxia in Diabetes

The absolute amount of endothelial precursor cells in 10 ml of blood

Senior consultant / associated professor

This is a randomised, double-blind, placebo-controlled, cross-over, single center study of patients with diabetes mellitus type 1 without chronic complications.

diabetes complications/dl prolina

Effect of Deferoxamine on Wound Healing Rate in Patients With Diabetes Foot Ulcers

Desferal Administration to Improve the Impaired Reaction to Hypoxia in Diabetes

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