A medical application of N-oleoyl-dopamine and 3'-O-methyl-N-oleoyl-dopamine for the production of a medication for treatment or prophylaxis of disturbances or states due to deficiency of dopamine, preferably chosen from the group covering oxygen deficiencies (hypoxia) in anesthetized and awake mammals, breathing with atmospheric oxygen (normoxia), for the respiratory responses to hypoxia in mammals, lack of dopamine binding to the membrane system in the mammalian brain, disturbances in metabolic pathways of dopamine metabolism, states of dopamine deficiencies provoked by morbid or genetic factors as well as under condition connected to the physiological process of aging of the organism, through the systemic introduction of the compound to the mammalian organism. A method of production of 3'-O-methyl-N-oleoyl-dopamine in vitro is also disclosed.

Pokorski; Mieczyslaw

Zajac; Dominika

Czarnocki; Zbigniew

Roszkowski; Piotr

Instytut Medycyny Doswiadczalnej i Klinicznej im. M. Mossakowskiego PAN

Uniwersytet Warszawski

Medical application of lipid derivatives of dopamine and the methods of their production

Genes and the proteins encoded thereby that are involved in stroke response and/or are regulated by FK506 are disclosed. These genes were discovered using in vivo or in vitro stroke models by determining which genes were differentially upregulated or downregulated upon treatment of the model with FK506. They were also found by a functional assay of genes specifically selected for conferring to cells resistance to hypoxia, dopamine or glutamate treatment. The disclosure includes such genes and proteins as well as analogs, salts and functional derivatives of such proteins, and DNA encoding such analogs, and methods of use. Methods for treating the effects of stroke, hypoxia and/or ischemia by regulating such genes or proteins are disclosed. Methods for screening for compounds capable of regulating the genes and proteins of the invention are also disclosed.

Quark Biotech, Inc.

Fujitsawa Pharmaceutical Co., Ltd.

Genes involved in stroke response and/or regulated by FK506, proteins encoded thereby, and methods of use

A method of treating or preventing adhesion formation during or following a surgical procedure comprising administering to a patient in need thereof at least one medicament selected from the group consisting of potassium channels; modulators of macrophage activation and leucocyte attraction through cytokines, or their inhibitors, antibodies or inhibitors blocking the effect of VEGF expression; prostaglandin E1; free radical scavengers, lipid peroxysomes; pregnatrienes; calcium antagonists; hypoxia; acidosis; MP; dopamine; and ATP-MgCl.sub.2, wherein the method prevents adhesion formation by preventing anoxemia.

Saturnus AG

Adhesion prevention and an endoscopic insufflation system therefor

dopamine

hypoxia

dopamine/hypoxia

Medical application of lipid derivatives of dopamine and the methods of their production

Genes involved in stroke response and/or regulated by FK506, proteins encoded thereby, and methods of use

Adhesion prevention and an endoscopic insufflation system therefor

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