Stratum 1: From 3 months to <18 months= 175 Stratum 2: From 18 months to 59 months= 175
In total, 350 participants will be enrolled

Acute Diarrhea

Half of the tablet (10 mg) for 3 to 6 months old children and one tablet (20 mg) daily for > 6 to 59 months old children. The tablet will be dissolved in a teaspoon of safe water or breast milk and administered once daily for 10 days.

Zinc Sulfate Dispersible Tablet 20 mg (Elemental Zinc 20 mg as Zinc Sulfate Monohydrate / Tablet)

Zinc Sulfate Acceptability

Zinc Sulfate Acceptability Study in Children With Acute Diarrhea: A Prospective, Open-label, Interventional Study

The treatment will be considered to have good acceptability if 80% of the prescribed treatment is taken by at least 70% of the children.

A subjective evaluation measured on the basis of a caregiver's report of his/her child's behavior (through a 5-point pictorial Hedonic scale) during the 10 days when the medicine is administered. A 'Diary Card' will be provided to the caregiver for keeping the daily records of the events.

International Centre for Diarrhoeal Disease Research, Bangladesh

Stratum 1: From 3 months to <18 months= 175 Stratum 2: From 18 months to 59 months= 175
in total, 350 participants will be enrolled

Clostridium Difficile Infection (CDI)

Antibodies react with C. difficile toxin, C. difficile bacteria and spores; neutralizes the toxin and inhibit the growth of spores and vegetative forms of C. difficile

IM-01

Foothills Medical Center

Treatment of Mild-moderate Clostridium Difficile Infection (CDI)

Clinical Effectiveness of Egg-derived Polyclonal Antibodies (IM-01) for the Treatment of Mild-moderate Clostridium Difficile Infection (CDI)

Decrease the frequency of unformed bowel motions to less than 3 per day and sustain for the duration of treatment to 10-14 days.

To enumerate numbers of C.difficile present per g of stool by dilution at plate counts on CCFA or Biomerieux C. difficile Chrom Agar , Total counts on three plates express as log 10 count /g versus spore counts after alcohol shock. Toxin titers: expressed as 1/dilution of the fecale filtrate neutralized by specific anti-toxin antibodies from Tech Lab using the CCNA test. .

In those that responded to treatment with resolution of CDI, the rate of recurrence of CDI in a 30, 42 and 56 day follow up period.
• Exploratory outcome: patterns of C. difficile microbial counts and toxin titres in relationship to clinical outcomes from treatment assignments

ImmuniMed Inc.

University of Calgary

University of Manitoba

Twenty four patients in each group will receive IM-01 treatment at 20g or 10g or 5g twice daily:for 10-14 days.

Patients will be randomized 1:1:1 to receive IM-01 treatment dosage at 20g or 10g or 5g twice a day

dysentery/albumina

Zinc Sulfate Acceptability

Treatment of Mild-moderate Clostridium Difficile Infection (CDI)

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