Glomerulonephritis / protease

Peptoid and nonpeptoid containing .alpha.-keto oxadiazoles as serine protease inhibitors

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BACKGROUND OF THE INVENTION The serine proteases are a class of enzymes, which includes elastase, chymotrypsin, cathepsin G, trypsin and thrombin. These proteases have in common a catalytic triad consisting of Serine-195, Histidine-57 and Aspartic acid-102(chymotrypsin numbering system). Human

Peptoid and nonpeptoid containing alpha-keto oxadiazoles as serine protease inhibitors

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BACKGROUND OF THE INVENTION The serine proteases are a class of enzymes, which includes elastase, chymotrypsin, cathepsin G, trypsin and thrombin. These proteases have in common a catalytic triad consisting of Serine-195, Histidine-57 and Aspartic acid-102(chymotrypsin numbering system). Human

Derivatives, having an inhibitory action against protease and an antiphlogistic action, of the trypsin-kallikrein inhibitor obtained from cattle organs (BPTI), their preparation and their use as medicaments

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The present invention relates to new derivatives of trypsin-kallikrein inhibitor, obtainable from cattle organs, which is called BPTI (basic pancreatic trypsin inhibitor [Kunitz]) in the text which follows, and to processes for the preparation of these derivatives from natural BPTI or from

Serine protease inhibitors-N-substituted derivatives

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The present invention relates to certain substituted oxadiazole, thiadiazole and triazole peptoids which are useful as inhibitors of serine proteases. BACKGROUND OF THE INVENTION The serine proteases are a class of enzymes which includes elastase, chymotrypsin, cathepsin G, trypsin and thrombin.

Serine protease inhibitors-keto and di-keto containing ring systems

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The present invention relates to certain substituted oxadiazole, thiadiazole and triazole peptoids which are useful as inhibitors of serine proteases. BACKGROUND OF THE INVENTION The serine proteases are a class of enzymes which include elastase, chymotrypsin, cathepsin G, trypsin and thrombin.

Val-pro containing .alpha.-keto oxadiazoles as serine protease inhibitors

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BACKGROUND OF THE INVENTION The serine proteases are a class of enzymes, which includes elastase, chymotrypsin, cathepsin G, trypsin and thrombin. These proteases have in common a catalytic triad consisting of Serine-195, Histidine-57 and Aspartic acid-102 (chymotrypsin numbering system). Human

Indole and tetrahydroisoquinoline containing Alpha-keto oxadiazoles as serine protease inhibitors

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The present invention relates to certain substituted oxadiazole nonpeptides, which are useful as inhibitors of serine proteases. BACKGROUND OF THE INVENTION The serine proteases are a class of enzymes, which includes elastase, chymotrypsin, cathepsin G, trypsin and thrombin. These proteases have in

Serine protease inhibitors-proline analogs

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The present invention relates to certain substituted oxadiazole, thiadiazole and triazole peptoids which are useful as inhibitors of serine proteases. BACKGROUND OF THE INVENTION The serine proteases are a class of enzymes which includes elastase, chymotrypsin, cathepsin G, trypsin and thrombin.

Serine protease inhibitors

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The present invention relates to certain substituted oxadiazole nonpeptides, which are useful as inhibitors of serine proteases. BACKGROUND OF THE INVENTION The serine proteases are a class of enzymes, which includes elastase, chymotrypsin, cathepsin G, trypsin and thrombin. These proteases have in

Serine protease inhibitor--tripeptoid analogs

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The present invention relates to certain substituted oxadiazole, thiadiazole and triazole peptoids which are useful as inhibitors of serine proteases. BACKGROUND OF THE INVENTION The serine proteases are a class of enzymes which includes elastase, chymotrypsin, cathepsin G, trypsin and thrombin.

Serine protease inhibitors-cycloheptane derivatives

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BACKGROUND OF THE INVENTION The serine proteases are a class of enzymes which includes elastase, chymotrypsin, cathepsin G, trypsin and thrombin. These proteases have in common a catalytic triad consisting of Serine-195, Histidine-57 and Aspartic acid-102 (chymotrypsin numbering system). Human

Nitrile derivatives that inhibit cathepsin K

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BACKGROUND OF THE INVENTION 1. Field The present invention relates to novel nitrile derivatives, their manufacture and use as medicaments. In particular, the invention relates to novel nitrile derivatives of formula (I) 2. Description Cysteine proteases have been viewed as lysosomal mediators of

Heteroaryl nitriles

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BACKGROUND OF THE INVENTION Cysteine proteases have been viewed as lysosomal mediators of terminal protein degradation. Several newly discovered members of this enzyme class, however, are regulated proteases with limited tissue expression, which implies specific roles in cellular physiology and thus

Beta-amino acid nitrile derivatives as cathepsin K inhibitors

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FIELD OF THE INVENTION The present invention relates to novel beta-amino acid nitrile derivatives, their manufacture and use as medicaments. In particular, the invention relates to novel beta-amino acid nitrile derivatives of formula (I) ##STR1## wherein R.sup.1 represents hydrogen, aryl,

Protein and DNA thereof

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TECHNICAL FIELD The present invention relates to a novel ADAM protein. BACKGROUND ART An extracellular matrix is a cell-supporting tissue surrounding cells of the tissue and is composed of a fibrous protein such as collagen and elastin, a complex carbohydrate such as proteoglycan, a glycoprotein

glomerulonephritis/protease

Peptoid and nonpeptoid containing .alpha.-keto oxadiazoles as serine protease inhibitors

Peptoid and nonpeptoid containing alpha-keto oxadiazoles as serine protease inhibitors

Derivatives, having an inhibitory action against protease and an antiphlogistic action, of the trypsin-kallikrein inhibitor obtained from cattle organs (BPTI), their preparation and their use as medicaments

Serine protease inhibitors-N-substituted derivatives

Serine protease inhibitors-keto and di-keto containing ring systems

Val-pro containing .alpha.-keto oxadiazoles as serine protease inhibitors

Indole and tetrahydroisoquinoline containing Alpha-keto oxadiazoles as serine protease inhibitors

Serine protease inhibitors-proline analogs

Serine protease inhibitors

Serine protease inhibitor--tripeptoid analogs

Serine protease inhibitors-cycloheptane derivatives

Nitrile derivatives that inhibit cathepsin K

Heteroaryl nitriles

Beta-amino acid nitrile derivatives as cathepsin K inhibitors

Protein and DNA thereof

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