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greater/hyoscine

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Routine use of hyoscine N butylbromide (Buscopan) in double contrast barium enema examinations.

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A retrospective analysis of the effect of oral and intravenous hyoscine N butylbromide (Buscopan) on the dimensions of the large bowel during double contrast barium enema (DCBE) examination was made and compared with corresponding measurements without Buscopan. It was found that 20 mg oral Buscopan

Pre-operative medication reviewed: oral temazepam compared with papaveretum and hyoscine.

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Oral temazepam was compared with papaveretum and hyoscine for pre-operative medication. The oral premedication was associated with less subjective unpleasant side-effects and greater anxiolytic properties. It was adjudged to be superior by the anaesthetic and nursing staff as well as by the patients

Comparison of buprenorphine-hyoscine and papaveretum-hyoscine as premedicants for gynaecological surgery.

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Buprenorphine 0.3 mg and papaveretum 20 mg, both combined with hyoscine 0.4 mg, were used as premedicants in female patients undergoing laparoscopy or abdominal hysterectomy. The effects were compared. It was found that the increase in drowsiness and tranquility was greater following buprenorphine

[The effect of a synthetic anticholinergic agent, N-methyl hyoscine methyl sulfate, on the exocrine pancreatic secretion of the alert dog].

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The inhibitory action of N-methyl hyoscine methyl sulphate (N-methyl scopolamine, an anticholinergic drug) has been studied on the exocrine pancreatic secretion stimulated by secretin + caerulein on the conscious dog provided with Thomas cannulae. The dose-response curve shows an "all or nothing"
1. At 37 degrees C in 0.1 M NaCl the pKa of hyoscine (10 mM) is 7.53; the non-protonated form has about one-tenth of the affinity (log K = 8.58) of the protonated form (log K = 9.58) for muscarine-sensitive receptors of the guinea-pig ileum at 37 degrees C. 2. In the same conditions the pKa of

Effect of hyoscine N-butylbromide on gastroesophageal reflux in normal subjects and patients with gastroesophageal reflux disease.

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OBJECTIVE Recent studies have shown that atropine reduces gastroesophageal reflux in normal subjects and patients with gastroesophageal reflux. The aim of the study has been to assess the effects of an atropine derivative, hyoscine N-butylbromide in normal subjects and patients with gastroesophageal
A double-blind crossover trial with a 4-point bioassay was carried out in 8 convalescent in-patients to study the relative potency of scopolamine-N-(cyclopropyl methyl) bromide (DA 3177), a new parasympatholytic drug, administered at doses of 2.5 mg and 5 mg i.v., and hyoscine-N-butyl bromide,

Haemodynamic effects of hyoscine-N-butylbromide in ponies.

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The haemodynamic effects of hyoscine-N-butylbromide (0.30 mg/kg, intravenously) were studied in eight adult ponies in a blinded two-period crossover experiment with repeated measures. Values for heart rate were 63%, 48% and 13% greater than control values at 1, 16 and 46 min, respectively, after

Inhibitory responses to nicotine and transmural stimulation in hyoscine-treated guinea-pig isolated trachealis: an electrical and mechanical study.

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Guinea-pig isolated trachealis muscle treated with hyoscine (1 microM) exhibited mechanical tone which could be suppressed by transmural stimulation and, in a concentration-dependent manner, by nicotine (10-1000 microM). Hexamethonium (500 microM) did not itself cause tone changes, antagonized
OBJECTIVE In man a neurokinin-1 (NK1) receptor antagonist has previously been shown to be ineffective in the prevention of motion-induced nausea. The antiemetic efficacy of NK1 receptor antagonists against chemotherapy-induced emesis is, however, enhanced when combined with a 5-HT3 receptor

Analgesic effects of acetaminophen, diclofenac and hyoscine N-butylbromide in second trimester pregnancy termination: a prospective randomized study.

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OBJECTIVE This prospective, randomized study aimed to compare the analgesic effects of acetaminophen, diclofenac and hyoscine-N-butylbromide (HnBB) in cases of second trimester pregnancy termination. METHODS In 60 women with indications for second trimester pregnancy termination, three analgesic

Pharmacokinetics and clinical response of hyoscine plus morphine premedication in connection with cardiopulmonary bypass surgery.

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Plasma hyoscine and morphine levels and various pharmacodynamic responses have been examined in seven patients scheduled for a coronary-artery bypass graft. Hyoscine 0.006 mg kg-1 and morphine 0.20 mg kg-1 were administered intramuscularly as routine premedication. Surgery was performed using

The selectivity of the (-)-and (+)-forms of hyoscine methiodide and of hyoscyamine camphorsulphonate for muscarinic (M2) receptors.

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The affinities of (-)-S-hyoscyamine (+)-camphorsulphonate, (+)-R-hyoscyamine (-)-camphorsulphonate, (-)-S-hyoscine methiodide and (+)-R-hyoscine methiodide for muscarinic acetylcholine receptors in guinea-pig atria and ileum at 30 degrees C and in ileum at 37 degrees C have been measured in

Emergency department management of undifferentiated abdominal pain with hyoscine butylbromide and paracetamol: a randomised control trial.

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OBJECTIVE To compare the effectiveness of paracetamol, hyoscine butylbromide and the combination of paracetamol plus hyoscine butylbromide (paracetamol + hyoscine butylbromide) in the management of patients with acute undifferentiated abdominal pain attending the emergency department (ED). METHODS A
BACKGROUND A prospective, double-blinded, placebo-controlled randomized trial was conducted to investigate the effect of the antispasmodic hyoscine N-butyl bromide (Buscopan) during colonoscopy. METHODS A total of 120 patients undergoing colonoscopy were randomized to receive either 40 mg of
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