1 ml of 20 mg Parecoxib is given concurrently with 19 mls of 0.75% ropivacaine

19 ml of Ropivacaine at a concentration of 0.75% is given concurrently with 1 ml of 0.9% saline

Anesthesia; Functional

Anesthesia

1 ml of injectable parecoxib (Dynastat®, Pfizer) at a concentration of 20 mg/mL is given concurrently with 19 ml of 0.75% ropivacaine (Naropin®, Astra Zeneca)

Parecoxib 20 MG/ML

19 ml of 0.75% ropivacaine (Naropin®, Astra Zeneca)) is given concurrently with 1 ml of normal saline

Ropivacaine

PMC Free article link for Sterne JA et al article on multiple imputation

Hospital Universiti Sains Malaysia (HUSM)

The Efficacy of 20 mg Parecoxib as an Adjunct to 0.75% Ropivacaine in Supraclavicular Brachial Plexus Block for Upper Limb Surgery

A Randomized Two-parallel Group Controlled Trial Comparing the Effects of 20mg Parecoxib as an Adjunct to 0.75% Ropivacaine in Ultrasound-guided Supraclavicular Block for Upper Limb Surgery

Time (measured in minutes) required for a 30% decrease in sensation compared to the contralateral upper limb limb as a reference

Time (measured in minutes) from the injection of interventions until a decrease in motor power to at least grade 3

The time (measured in hours) from the injection of interventions until complete recovery in cold and pain sensation confirmed by alcohol swab and pin prick tests in all respective dermatomes of the brachial plexus (C5-T1)

Time (measured in hours) from the injection of allotted interventions until complete recovery of motor power (grade 1) in all dermatomes supplied by brachial plexus (C5-T1)

The presence of complete sensory block at 30 minutes following institution of allotted intervention

The presence of full motor block at 30 minutes following institution of allotted interventions

All individual participant data (IPD) will be shared with other researchers. These include all primary and secondary outcomes of interest and covariate information which include the clinical and demographic profiles of patients.

Wan Nor Arifin Wan Mansor

Universiti Sains Malaysia

A continuous intravenous infusion of lidocaine

A continuous intravenous infusion of saline

A continuous intravenous infusion of lidocaine
Lidocaine infusion: Lidocaine intravenous 2mg/kg initial bolus over 5 minutes followed by a continuous intravenous infusion of lidocaine at a rate of 2mg /kg /hour for 4 hours

Lidocaine Infusion

A continuous intravenous infusion of saline
Saline infusion: A continuous intravenous infusion of saline at the same volume with lidocaine infusion for 4 hours

Saline Infusion

Total

Sex: Female, Male

Region of Enrollment

Visual Analog Pain Scores on a scale of 0 to 10 (0=no pain and 10=worst pain)

Intensity of Pain

The time to withdraw at the Cold Pressor Task immediately after 4-hours intravenous continuous lidocaine infusion

Withdrawal Time (Seconds)

Overall Study

Enas Kandil

Chronic Pain

Lidocaine intravenous 2mg/kg initial bolus over 5 minutes followed by a continuous intravenous infusion of lidocaine at a rate of 2mg /kg /hour for 4 hours

Lidocaine infusion

A continuous intravenous infusion of saline at the same volume with lidocaine infusion for 4 hours

hyperalgesia/napad padaczkowy

The Efficacy of 20 mg Parecoxib as an Adjunct to 0.75% Ropivacaine in Supraclavicular Brachial Plexus Block for Upper Limb Surgery

Lidocaine Infusion for Chronic Pain in Opioid Dependent Patients

Propofol Injection for Daily Headache

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