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hyperkalemia/hypoxia

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Spurious hypoglycemia, hyperkalemia and hypoxemia in chronic hemolytic anemia.

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Spurious hypoglycemia and hyperkalemia were found in a patient with chronic hemolytic anemia due to an unidentified hemoglobinopathy. The patient had massive reticulocytosis, and many nucleated red blood cells were present in his blood smear. Hypoxemia was induced in vitro. No correlation was found

Electrophysiological responses of hypertrophied rat myocardium to combined hypoxia, hyperkalemia, and acidosis.

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We studied whether electrophysiological response to ischemia could be different in hypertrophied left ventricle of spontaneously hypertensive rats (SHRs) and in normal left ventricle of normotensive Wistar-Kyoto (WKY) rats. For that purpose, we used a two-compartment tissue bath in which one-half of

Purkinje-muscle coupling and endocardial response to hyperkalemia, hypoxia, and acidosis.

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Previously we found that combined hyperkalemia, hypoxia, and acidosis depressed the electrical activity of canine epicardium more than that of endocardium or Purkinje fibers. In this study, we determined whether the resistance of endocardium to these components of ischemia was due to electrotonic
Standard microelectrode methods were used to record intracellular action potentials from strips of guinea pig right ventricular myocardium superfused with either standard physiological saline (pH 7.3; PO2 greater than 650 mm Hg; [K+] = 5.6 mM) or the same solution modified to produce either

Effects of hypoxia, hyperkalemia, and metabolic acidosis on canine subendocardial action potential conduction.

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We have studied the individual and combined effects of elevated external potassium concentration (8 mM [K+], metabolic acidosis (pH = 6.8), and hypoxia at different stimulation 400 milliseconds) on Purkinje (P) and ventricular (V) conduction velocities and on Purkinje-ventricular junctional

Combined effects of hypoxia, hyperkalemia and acidosis on membrane action potential and excitability of guinea-pig ventricular muscle.

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The effects of hypoxia (with and without acidosis) on membrane action potentials and recovery kinetics of their upstroke velocity (Vmax) were studied in isolated guinea-pig papillary muscles at various extracellular K+ concentrations. At 5 mM [K+]0, hypoxia (hypoxic and glucose-free perfusate) at pH
As rainbow trout approach exhaustion during prolonged exercise, they maintain maximum cardiac output despite the fact their venous blood, which bathes the heart, becomes hypoxic, acidotic and hyperkalemic. Because these factors are individually recognized to have detrimental inotropic and

Different electrophysiological responses of canine endocardium and epicardium to combined hyperkalemia, hypoxia, and acidosis.

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Using microelectrode techniques, we examined the effects of the slow channel blockers diltiazem, nifedipine and Ni2+ on the tissue deterioration induced by a modified superfusion solution imitating some of the metabolic changes in acute myocardial ischemia (pO2 = 4.0--5.1 kPa, [K+] = 8 mmol/l, pH =
During ischemia, lidocaine or quinidine may prevent arrhythmias by blocking conduction without suppressing abnormal automaticity. The purpose of this study was to determine whether lidocaine or quinidine (5 micrograms/ml) produced Purkinje fiber-papillary muscle block during superfusion in vitro
We examined the effects of verapamil and lidocaine on changes in action potential characteristics and conduction time in the isolated right ventricular myocardium of canine hearts during superfusion with altered Tyrode's solution imitating some of metabolic alterations that occur in acute myocardial

Effects of procaine on hypoxia induced abnormalities in canine myocardial tissues.

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Combined effects of hypoxia, hyperkalemia and acidosis (HH&A) produced contracture (increased resting tension) in canine ventricular muscle tissues but not in Purkinje fibers perfused for the same length of time. Administration of procaine during such contracture stabilized the resting tension

Behavioral strategy and the physiological stress response in rainbow trout exposed to severe hypoxia.

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In higher vertebrates, two opposite behavioral coping strategies can be distinguished that are associated by a typical neuroendocrine pattern. Little is known about the individual variation in the stress response in lower vertebrates such as teleosts. In the present study, rainbow trout were fitted

[Protective effects of nicorandil on action potentials in anoxia and reoxygenated ventricular myocardium of guinea pig].

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Standard microelectrode techniques were used to study the effects of nicorandil (500 mumol.L-1) on action potentials in anoxia and reoxygenated ventricular myocardium of guinea pig. The main results: (a) Nicorandil shortened the action potentials duration (APD) and increased the ratio of effective
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