Pancreatic Necrosis

serum mitochondrial DNA will be measured using RT-PCR within first 72 hours of symptoms of acute pancreatitis

serum mitochondrial DNA

Predicting Pancreatic Necrosis Using mitDNA

Study of Plasma mitDNA in Predicting Pancreatic Necrosis in Acute Pancreatitis

level of serum mitochondrial DNA in severe acute pancreatitis

Soha Mohammad Nageb

spechialist

Assiut University

Eligible subjects will be randomized to one of the two treatment group in1:1 ratio to receive either DEX or matching placebo (PBO, LR).

Subjects undergoing one or two level spinal fusion surgery will be screened for eligibility to participate in the study. Subject will be screened, recruited and randomized during the preadmission visit or the day of surgery. Eligible subjects will be randomized to one of the two treatment group in1:1 ratio to receive either DEX or matching placebo (PBO, LR).

Placebo Group

Fifty six subjects (28 in each arm) will be enrolled. Subjects undergoing one or two level spinal fusion surgery will be screened for eligibility to participate in the study. Subject will be screened, recruited and randomized during the preadmission visit or the day of surgery. Eligible subjects will be randomized to one of the two treatment group in1:1 ratio to receive either DEX or matching placebo (PBO, LR).

Dexmedetomidine Group

Total

Sex: Female, Male

The QoR-40 is a 40 item questionnaire in which each question is answered with a score of 1-5. QoR-40 scores range from 40 (extremely poor quality of recovery) to 200 (excellent quality of recovery).

Anesthesia maintained with propofol/fentanyl/dexmedetomidine

Dexmedetomidine Group (PFD)

Anesthesia maintained with propofol/fentanyl/saline

immunostimulator/martwica

Predicting Pancreatic Necrosis Using mitDNA

Pilot Study on the Effect of Dexmedetomidine on Inflammatory Responses in Patients Undergoing Lumbar Spinal Fusion

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