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TECHNICAL FIELD
The presently disclosed subject matter relates generally to methods and tests for analyzing recurrent DNA copy number changes in tumor tissue samples from cancer subjects. Copy number is predictive of response to therapy, time of first remission, and in some cases overall
CROSS REFERENCE TO RELATED APPLICATIONS
The presently disclosed subject matter claims the benefit of U.S. Provisional Patent Application Ser. No. 61/284,164, filed Dec. 14, 2009, the disclosure of which is incorporated herein by reference in its entirety.
TECHNICAL FIELD
The presently disclosed
BACKGROUND OF THE INVENTION
1. Field of the Invention
The present invention relates to L-asparagine amidohydrolytic enzymes, more particularly, to polypeptides which originate from mammal, having L-asparaginase activity.
2. Description of the Prior Art
L-Asparaginase (EC 3.5.1.1) is an enzyme which
BACKGROUND OF THE INVENTION
1. Field of the Invention
The present invention relates to L-asparagine amidohydrolytic enzymes, more particularly, to polypeptides which originate from mammal, having L-asparaginase activity.
2. Description of the Prior Art
L-Asparaginase (EC 3.5.1.1) is an enzyme which
BACKGROUND OF THE INVENTION
1. Field of the Invention
The present invention relates to L-asparagine amidohydrolytic enzymes, more particularly, to polypeptides which originate from mammal, having L-asparaginase activity.
2. Description of the Prior Art
L-Asparaginase (EC 3.5.1.1) is an enzyme which
BACKGROUND OF THE INVENTION
1. Field of the Invention
The present invention relates to L-asparagine amidohydrolytic enzymes, more particularly, to polypeptides which originate from mammal, having L-asparaginase activity.
2. Description of the Prior Art
L-Asparaginase (EC 3.5.1.1) is an enzyme which
BACKGROUND OF THE INVENTION
Field of the Invention
The present invention concerns a conjugate of a protein having substantial L-asparagine aminohydrolase activity and polyethylene glycol, particularly wherein the polyethylene glycol has a molecular weight less than or equal to about 5000 Da,
SEQUENCE LISTING
Incorporated by reference in its entirety herein is a computer-readable nucleotide/amino acid sequence listing submitted concurrently herewith and identified as follows: One 26,355 Byte ASCII (Text) file named "708084ST25.txt," created on May 2, 2011.
BACKGROUND OF THE
BACKGROUND OF THE INVENTION
Asparagine is a naturally occurring amino acid that is found in many proteins. Asparagine synthetase (ASNS) is involved in asparagine biosynthesis. L-asparaginase (L-ASP) is an enzyme that catabolizes asparagine. L-ASP has been used in the treatment of acute lymphoblastic
RELATED APPLICATION INFORMATION
This application is a 371 of International Application PCT/CN2015/072167 filed 3 Feb. 2015, which claims priority from Chinese Application No. 201410837456.3 filed on 29 Dec. 2014, the disclosures of which are incorporated in their entirety by reference herein.
FIELD