Prepared by solving lycopene powder in a solvent (ethanol: propylene glycol: water in the ratio of 50:30:20). The solution was then gelled by adding 8% hydroxypropyl cellulose (HPC). The concentration of the prepared gel equals to 2%.
After scaling, root planing, and polishing (SRP), the gel delivered into periodontal pocket using insulin syringes, the therapeutic dose is about 2mg/0.1 ml.

Minocycline HCL Microspheres, 1mg minocycline powder per cartridge. A locally applied antibiotic that is placed directly into the infected periodontal pocket following SCR.

Used to irrigate periodontal pockets after SRP

Periodontal Pocket

Prepared by solving lycopene powder in a solvent (ethanol: propylene glycol: water in the ratio of 50:30:20). The solution was then gelled by adding 8% hydroxypropyl cellulose (HPC). The concentration of the prepared gel equals to 2%.
After SRP, the gel delivered into periodontal pocket using insulin syringes, the therapeutic dose is about 2mg/0.1 ml.

Lycopene

Minocycline HCl Microspheres, 1mg minocycline powder per cartridge. A locally applied antibiotic that is placed directly into the infected periodontal pocket following SCR.

Minocycline HCl 1mg Oral Powder

Distilled water

College of Dentistry/ University of Baghdad

Lycopene vs Minocycline Hydrochloride as Adjunctive to Periodontal Treatment

The Effect of Lycopene Antioxidant Gel Compared to Minocycline Hydrochloride Microspheres as Adjunctive to Non Surgical Periodontal Treatment by Measuring Matrix Metalloproteinase-9, Transforming Growth Factor-Beta 1, Interleukin-8, and Tissue Inhibitor of Metalloproteinases -1

Level of selected inflammatory markers (MMP-9, TGF-Beta 1, IL-8, TIMP-1) is measured in the gingival crevicular fluid before and after use of different interventions

Clinical attachment level (CAL) is measured at baseline and after using different interventions

Measuring bleeding on probing (BOP), indicated by score 0 (no bleeding) score 1 (bleeding), from periodontal pockets treated with different interventions at baseline and at the end of the trial period.

Ali A Abdulkareem

Lecturer

University of Baghdad

Group 1(ASA) included 33 patients who received acetylsalicylic acid at a dose of 75 mg orally once a day in the morning.

Group 2 (STE) included 32 patients receiving tomato fruit extract (STE) (ZAAX, Sequia, Poland) at a dose of 213 mg orally once a day in the morning.

Hypertension,Essential

Obesity

Group 1(ASA) included 33 patients who received acetylsalicylic acid at a dose of 75 mg in the morning

acetylsalicylic acid

Group 2 (STE) included 32 patients receiving standardized tomato extract (STE) (ZAAX, Sequia, Poland) at a dose of 213 mg orally in the morning

Tomato Fruit Extract

Antiplatlet Effects of Standardized Tomato Extract in Hypertensive Subjects

Antiplatlet Effects of Standardized Tomato Extract in Hypertensive Subjects at High Estimated Cardiovascular Risk

The platelet inhibition after STE and ASA therapy (VerifyNow Aspirin for ASA and STE Groups and VerifyNow P2Y12 for STE Group only) The platelet reactivity measurements will be performed using the VerifyNow Tests (Accumetrics Inc., USA) method.

The reduction in office BP (measured three times in standard conditions) and in 24-hour ABPM parameters

Beata Krasinska

Principal Investigator

Subarachnoid Hemorrhage

Aneurysm

placebo

Addenbrooke's Hospital

Lycopene Following Aneurysmal Subarachnoid Haemorrhage

Acute Oral Lycopene Therapy on Cerebral Autoregulation and Delayed Ischaemic Deficits Following Aneurysmal Subarachnoid Haemorrhage (LASH): A Randomized Controlled Trial

Mean flow velocity in MCA > 120 cm/min; LR > 3 (4 if age < 50 years old)

Mr Peter John Kirkpatrick

University of Cambridge

Cambridge Theranostics Ltd

Both arms are double-blinded. Infant will be assigned to receive preterm formula with added carotenoids. If infant is receiving human milk then the study formula will only be used as a supplement.

Both arms are double-blinded. This arm will use preterm formula as it is currently available, which is without any carotenoids. If the infant is receiving human milk, then the formula will be used as a supplement as needed.

lycopene/krwotok

Lycopene vs Minocycline Hydrochloride as Adjunctive to Periodontal Treatment

Antiplatlet Effects of Standardized Tomato Extract in Hypertensive Subjects

Lycopene Following Aneurysmal Subarachnoid Haemorrhage

Skin and Serum Carotenoids in Preterm Infants Fed on a Formula Supplemented With Carotenoids

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