Lymphoma / tyrosine

Reagents for the detection of protein phosphorylation in anaplastic large cell lymphoma signaling pathways

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RELATED APPLICATIONS This application claims the priority benefit of U.S. Ser. No. 10/777,893, filed Feb. 12, 2004 (now U.S. Pat. No. 7,300,753), and PCT/US04/21670 filed Jul. 7, 2004. FIELD OF THE INVENTION The invention relates generally to antibodies and peptide reagents for the detection of

6-(2,3-dihydro-1H-pyrido-[2,3-b][1,4]oxazin-7-yl)-N-(4-morpholinophenyl)im- idazo[1,2-a] pyrazin-8-amine as a spleen tyrosine kinase inhibitor

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STATEMENT REGARDING FEDERALLY SPONSORED RESEARCH OR DEVELOPMENT Not Applicable. THE NAMES OF PARTIES TO A JOINT RESEARCH AGREEMENT Not Applicable INCORPORATION-BY-REFERENCE OF MATERIAL SUBMITTED ON A COMPACT DISC Not Applicable BACKGROUND OF THE INVENTION (1) Field of the Invention (2) Description

Pyrazolopyrimidine derivatives useful as inhibitors of Bruton's tyrosine kinase

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This invention relates to compounds. More specifically, the invention relates to compounds useful as kinase inhibitors, along with processes to prepare the compounds and uses of the compounds. Specifically, the invention relates to inhibitors of Bruton's tyrosine kinase (BTK). BACKGROUND Kinases are

Pyrazolopyrimidine derivatives useful as inhibitors of Bruton's tyrosine kinase

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RELATED APPLICATIONS This application is a national phase filing under 35 U.S.C. 371 of International Application No. PCT/GB2015/051719, filed Jun. 11, 2015, which claims the benefit of and priority to United Kingdom Patent Application No. GB1410430.1, filed Jun. 11, 2014, the contents of which

Tyrosine kinase inhibitors

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FIELD OF THE INVENTION The present disclosure relates to the field of tyrosine kinase enzyme inhibition, in particular anaplastic lymphoma kinase (ALK) inhibition using novel small molecules. Provided are compounds capable to modulate ALK activity, compositions that comprise the compounds, and

Tyrosine kinase inhibitors

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FIELD OF THE INVENTION The present disclosure relates to the field of tyrosine kinase enzyme inhibition, in particular anaplastic lymphoma kinase (ALK) inhibition using novel small molecules. Provided are compounds capable to modulate ALK activity, compositions that comprise the compounds, and

Human ALK protein tyrosine kinase

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BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention is directed to the field of molecular genetics of cancer. Specifically, the present invention relates to human lymphomas in which a translocation between chromosomes 2 and 5 (referred to in the art as "t(2;5)") has occurred.

Combination of an anti-CD19 antibody and a Bruton's tyrosine kinase inhibitor and uses thereof

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This patent application is the U.S. National Stage of International Application No. PCT/EP2016/061744 filed May 25, 2016, which claims the benefit of EP 15196860.9 filed Nov. 27, 2015 and EP 15169124.3 filed May 26, 2015, each of which is incorporated by reference in its entirety. FIELD OF THE

Antibodies for recognition of alk protein tyrosine/kinase receptor

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BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention is directed to the field of molecular genetics of cancer. Specifically, the present invention relates to human lymphomas in which a translocation between chromosomes 2 and 5 (referred to in the art as "t(2;5)") has occurred.

Compositions for detecting mutant anaplastic lymphoma kinase in lung cancer

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FIELD OF THE INVENTION The invention relates generally to proteins and genes involved in cancer, and to the detection, diagnosis and treatment of cancer. BACKGROUND OF THE INVENTION Many cancers are characterized by disruptions in cellular signaling pathways that lead to aberrant control of cellular

Methods of treating lung cancer using inhibitors anaplastic lymphoma kinase

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FIELD OF THE INVENTION The invention relates generally to proteins and genes involved in cancer, and to the detection, diagnosis and treatment of cancer. BACKGROUND OF THE INVENTION Many cancers are characterized by disruptions in cellular signaling pathways that lead to aberrant control of cellular

Bruton's tyrosine kinase inhibitors

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BACKGROUND Signaling through the B-cell receptor (BCR) can lead to a range of biological outputs depending upon, in part, the developmental stage of the B-cell. Faulty signaling through the BCR can cause disregulation of the B-cell function and/or the formation of auto-antibodies which may lead to

Inhibitors of Bruton's tyrosine kinase

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FIELD OF THE INVENTION Described herein are compounds, methods of making such compounds, pharmaceutical compositions and medicaments containing such compounds, and methods of using such compounds and compositions to inhibit the activity of tyrosine kinases. BACKGROUND OF THE INVENTION Bruton's

Inhibitors of Bruton's tyrosine kinase

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FIELD OF THE INVENTION Described herein are compounds, methods of making such compounds, pharmaceutical compositions and medicaments containing such compounds, and methods of using such compounds and compositions to inhibit the activity of tyrosine kinases. BACKGROUND OF THE INVENTION Bruton's

Inhibitors of Bruton's tyrosine kinase

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FIELD OF THE INVENTION Described herein are compounds, methods of making such compounds, pharmaceutical compositions and medicaments containing such compounds, and methods of using such compounds and compositions to inhibit the activity of tyrosine kinases. BACKGROUND OF THE INVENTION Bruton's

lymphoma/tyrosine

Reagents for the detection of protein phosphorylation in anaplastic large cell lymphoma signaling pathways

6-(2,3-dihydro-1H-pyrido-[2,3-b][1,4]oxazin-7-yl)-N-(4-morpholinophenyl)im- idazo[1,2-a] pyrazin-8-amine as a spleen tyrosine kinase inhibitor

Pyrazolopyrimidine derivatives useful as inhibitors of Bruton's tyrosine kinase

Pyrazolopyrimidine derivatives useful as inhibitors of Bruton's tyrosine kinase

Tyrosine kinase inhibitors

Tyrosine kinase inhibitors

Human ALK protein tyrosine kinase

Combination of an anti-CD19 antibody and a Bruton's tyrosine kinase inhibitor and uses thereof

Antibodies for recognition of alk protein tyrosine/kinase receptor

Compositions for detecting mutant anaplastic lymphoma kinase in lung cancer

Methods of treating lung cancer using inhibitors anaplastic lymphoma kinase

Bruton's tyrosine kinase inhibitors

Inhibitors of Bruton's tyrosine kinase

Inhibitors of Bruton's tyrosine kinase

Inhibitors of Bruton's tyrosine kinase

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