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FIELD OF THE INVENTION
The present invention relates to isolated mutant SMO nucleic acids and proteins related to chemotherapeutic resistance of tumors and methods of screening for compounds that bind to SMO mutants, or modulate SMO activity, and to cancer diagnostics and therapies and in particular
SEQUENCE LISTING
The instant application contains a Sequence Listing which has been submitted via EFS-Web and is hereby incorporated by reference in its entirety. Said ASCII copy, created on Jul. 3, 2013, is named CIBT221102_Seq.txt, and is 16,819 bytes in size.
FIELD OF THE INVENTION
The present
SEQUENCE LISTING
The instant application contains a Sequence Listing which has been filed electronically in ASCII format and is hereby incorporated by reference in its entirety. Said ASCII copy, created on Aug. 8, 2018, is named CURGEN-0226_SL.txt and is 68,800 bytes in size.
BACKGROUND OF THE
SEQUENCE LISTING
The instant application contains a Sequence Listing, which has been submitted via EFS-Web and is hereby incorporated by reference in its entirety. Said ASCII copy, created on Apr. 15, 2016, is named CIBT220302_Seq.txt, and is 19,587 bytes in size.
FIELD OF THE INVENTION
The present
FIELD OF THE INVENTION
The present invention relates to isolated mutant SMO nucleic acids and proteins related to chemotherapeutic resistance of tumors and methods of screening for compounds that bind to SMO mutants, or modulate SMO activity, and to cancer diagnostics and therapies and in particular