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najas/martwica

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ArtykułyBadania klinicznePatenty
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[Toxic necrosis following a bite by Naja nigricollis, a therapeutic challenge].

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The surgical approach to snake bite lesions remains controversial. As a rule surgery is not recommended. However, the attitude towards severe local effects of envenoming should be revised and treatment made more aggressive, as our case report illustrates: following envenoming by Naja nigricollis,

Immediate active movement following Bitis arietans or Naja mossambica venom injection diminishes or prevents necrosis in mice.

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Tourniquet use, which localises necrotising snake venom to the bite site, is suspected to exacerbate local necrosis. In view of this, the effect of immediate active movement on the outcome of necrotising snake venom injection was investigated in mice. A minimal macroscopic necrotic dose of Bitis

Cardiotoxin 1 from cobra (Naja naja atra) venom causes necrosis of skeletal muscle in vivo.

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Cardiotoxin 1 from cobra (Naja naja atra) venom was tested for its ability to cause necrosis of skeletal muscle cells after i.m. injection into mice. Light and electron microscopic examination of tissue indicated that the toxin caused necrosis of skeletal muscle as early as 30 min after injection.

Necrosis, haemorrhage and complement depletion following bites by the spitting cobra (Naja nigricollis).

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The Spitting Cobra, Naja nigricollis, is widely and densely distributed in Africa. Fourteen patients with proven N. nigricollis bites, who were seen in the savanna region of Nigeria, did not exhibit the neurological signs, such as cranial nerve lesions and respiratory paralysis, expected following
Naja atra envenomation is one of the most significant clinical snakebite concerns in Taiwan. Taiwanese freeze-dried neurotoxic antivenom (FNAV) is currently used clinically for the treatment of cobra snakebite, and has been shown to limit the mortality of cobra envenomation to less than 1%. However,

A study of the pathogenesis of local skin necrosis induced by Naja nigricollis (spitting cobra) venom using simple histological staining techniques.

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The course of degeneration and regeneration of mouse skin following intradermal injection of spitting cobra (N. nigricollis) venom was investigated using simple histological staining techniques. Early changes observed were vascular congestion, oedema and degeneration of the skeletal muscle cell

Local necrosis induced by cobra (Naja naja atra) venom.

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Venoms of several Naja species found in Sub-Saharan Africa, and commonly known as "spitting cobras", induce a predominantly cytotoxic pattern of envenomings that may evolve into tissue necrosis and gangrene. Cytotoxic components of their venoms have been identified as members of the three-finger
The cytotoxin family of cobra venom proteins, also called cardiotoxins, can activate both necrotic and apoptotic cell death pathways in cancer cells. Cytotoxin 1 (CTX1)from Naja atra Cantor venom is a 60 amino acid, 6698 Da protein with as yet untested anticancer efficacy and cell selectivity. We

On the mode of action of basic phospholipase A2 from Naja nigricollis venom.

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A study has been made of the cytotoxic activity of basic phospholipase A2 of venom from Naja nigricollis on different types of cells and of the participation of esterase activity in this cytotoxic activity. It was previously shown that the cytotoxicity observed is not due to a contaminant, since the
The pathogenesis of myonecrosis induced by three different snake venoms was studied by light microscopic examination of skeletal muscle tissue taken at time periods ranging from 0.25 hr to 4 weeks after an intramuscular injection of the venom into mice. It was possible to identify different types of

Humanized-single domain antibodies (VH/VHH) that bound specifically to Naja kaouthia phospholipase A2 and neutralized the enzymatic activity.

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Naja kaouthia (monocled cobra) venom contains many isoforms of secreted phospholipase A2 (sPLA(2)). The PLA(2) exerts several pharmacologic and toxic effects in the snake bitten subject, dependent or independent on the enzymatic activity. N. kaouthia venom appeared in two protein profiles, P3 and

Protection against osteoarthritis in experimental animals by nanogold conjugated snake venom protein toxin gold nanoparticle-Naja kaouthia cytotoxin 1.

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OBJECTIVE Increased severity of osteoarthritis (OA) and adverse side effects of its treatment led to the search for alternative therapies. It was previously reported that snake venom protein toxin Naja kaouthia cytotoxin 1 (NKCT1) and gold nanoparticle (GNP) individually have potential against

Culturable Aerobic and Facultative Anaerobic Intestinal Bacterial Flora of Black Cobra (Naja naja karachiensis) in Southern Pakistan.

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Using morphological analysis and biochemical testing, here for the first time, we determined the culturable gut bacterial flora (aerobes and facultative anaerobes) in the venomous Black Cobra (Naja naja karachiensis) from South Asia. The findings revealed that these snakes inhabit potentially

Bites by the Philippine cobra (Naja naja philippinensis): prominent neurotoxicity with minimal local signs.

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We studied 39 patients envenomed by the Philippine cobra (Naja naja philippinensis). Neurotoxicity occurred in 38 cases and was the predominant clinical feature. Respiratory paralysis developed in 19 patients, and was often rapid in onset--in 3 cases apnea occurred within 30 min of the bite. There
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