Prednisolone 0.5 mg/kg/day for 4 weeks; 0.25 mg/kg/day for 4 weeks; 0.125 mg/kg/day for 4 weeks. Then taper by 5 mg every 2 weeks and discontinue. All doses will be rounded off to the nearest 5 mg (maximum duration of therapy, 4 months)

Deflazacort 0.75 mg/kg/day for 4 weeks; 0.375 mg/kg/day for 4 weeks; 0.1875 mg/kg/day for 4 weeks. Then taper by 6 mg every 2 weeks and discontinue. All doses will be rounded off to the nearest 6 mg (maximum duration of therapy, 4 months)

Allergic Bronchopulmonary Aspergillosis

Deflazacort

Prednisolone

Chest Clinic, Dept. of Pulmonary Medicine

Deflazacort vs. Prednisolone in Acute-stage ABPA

A Randomized Controlled Trial of Deflazacort vs. Prednisolone in Acute-stage Allergic Bronchopulmonary Aspergillosis

Weight at 2 months minus the baseline weight

((Baseline IgE minus serum total IgE at 2 months)/Baseline IgE) * 100

((Baseline IgE minus serum total IgE at 4 months)/Baseline IgE) * 100

Decline in serum total IgE levels by ≥25% AND clinical improvement or partial/total clearance (>50%) of chest radiographic lesions after two months

Decline in serum total IgE levels compared to the value at 2 months AND clinical improvement or partial/total clearance (>50%) of chest radiographic lesions after two months

50% increase in the 'new' baseline serum total IgE levels along with clinical or radiological deterioration

Cushingoid habitus, acne, striae, hypertension, hyperglycemia

Ritesh Agarwal

Professor

Postgraduate Institute of Medical Education and Research

Patients planned to undergoing total knee arthroplasty or total hip arthroplasty, following the ERAS perioperative care.

Patients planned to undergoing total knee arthroplasty or total hip arthroplasty, following the traditional perioperative care.

Arthroplasty, Replacement, Knee, Hip

The patients in the ERAS group were given a pre-treatment drug [300 mg (gabapentin, Neurontin 300mg) and 10 mg oxycontin (oxycontin, Oxycontin CR 10mg) and 2 mg prednisolone (prednisolone 10 mg, Solondo 5mg)] on the evening before surgery. And pre-operative fasting should not exceed 6 hours, and clear liquid fasting should not exceed 2 hours. In addition, 400 ml of oral carbohydrate should be taken 2 to 4 hours before surgery to ensure adequate blood sugar and encourage regular diet (light meal) as soon as possible within a tolerable range after surgery. The initial pain after surgery is actively controlled by oral drugs such as celebrex and IR codon, and injections such as tramadol and demerol. On the first postoperative day, the urinary catheter is removed and CPM (continuous passive motion) rehabilitation is started.

Enhanced recovery after surgery (ERAS)

Department of Orthopedic Surgery, Yonsei University, College of Medicine

Prospective Randomized Controlled Trial of Impact of Enhanced Recovery After Surgery(ERAS) for Outcomes of Total Knee and Hip Arthroplasty

Before surgery, QoR40 questionnaires will be used to compare the quality of recovery after anesthesia. QoR40 is a 40 items quality of recovery score that has been validated in a diverse group of patients. It is comprised of five dimensions which are physical comfort (12 items), emotional state (9 items), physical independence (5 items), psychological support (7 items), and pain (7 items). Each item of the questionnaire is graded on a five-point Likert scale, and the global QoR-40 scores range from 40 (extremely poor quality of recovery) to 200 (excellent quality of recovery).

After surgery, QoR40 questionnaires will be used to compare the quality of recovery after anesthesia. QoR40 is a 40 items quality of recovery score that has been validated in a diverse group of patients. It is comprised of five dimensions which are physical comfort (12 items), emotional state (9 items), physical independence (5 items), psychological support (7 items), and pain (7 items). Each item of the questionnaire is graded on a five-point Likert scale, and the global QoR-40 scores range from 40 (extremely poor quality of recovery) to 200 (excellent quality of recovery).

The investigators will record the entire length of hospital stay.

The investigators will record how soon the patients have started a normal meal, assisted walking and continuous passive movement rehabilitation after surgery.

The investigators will investigate mortality up to 6 months after surgery.

The investigators will investigate morbidity up to 6 months after surgery.

The investigators will investigate postoperative complication of surgery up to 6 months after surgery.

The investigators will investigate number of readmission up to 6 months after surgery.

The investigators will record the clinical score of total joint arthroplasty(VAS) at 3 months after surgery.

The investigators will record the clinical score of total joint arthroplasty(WOMAC, The Western Ontario and McMaster Universities Arthritis) at 3 months after surgery.

The investigators will record the clinical score of total joint arthroplasty(AKS, American knee society score) at 3 months after surgery.

The investigators will record the clinical score of total joint arthroplasty(knee ROM) at 3 months after surgery.

The investigators will record the clinical score of total joint arthroplasty(Patellofemoral score) at 3 months after surgery.

The investigators will record the clinical score of total joint arthroplasty(Harris hip score) at 3 months after surgery.

The investigators will record the clinical score of total joint arthroplasty(VAS) at 6 months after surgery.

The investigators will record the clinical score of total joint arthroplasty(WOMAC, The Western Ontario and McMaster Universities Arthritis) at 6 months after surgery.

The investigators will record the clinical score of total joint arthroplasty(AKS, American knee society score) at 6 months after surgery.

The investigators will record the clinical score of total joint arthroplasty(knee ROM) at 6 months after surgery.

The investigators will record the clinical score of total joint arthroplasty(Patellofemoral score) at 6 months after surgery.

The investigators will record the clinical score of total joint arthroplasty(Harris hip score) at 6 months after surgery.

osteonecrosis/carbohydrate

Deflazacort vs. Prednisolone in Acute-stage ABPA

Prospective Randomized Controlled Trial of Impact of Enhanced Recovery After Surgery(ERAS) for Outcomes of Total Knee and Hip Arthroplasty

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