Patients will have periodic fasting for 4 weeks prior to the treatment cycle. The fasting method involves daily fasts of 14-16hours and restrict eating to an 8-10 hour "eating window" as 2-3 or more meals of balanced diet with 2-3 litres of water and non calorie fluids allover the day.

Patients will have usual balanced diet as 3 meals and 2 snacks all over the day. Both groups should take adequate water and non calorie beverages intake daily ( 2-3 liters daily)

Infertility

Polycystic Ovary Syndrome

No food for 14 -16 hours with water intake and non caloric beverages then eating balanced meals over 8 to 10 hours

Fasting

KasrELAiniH

The Effect of Fasting on ICSI Outcomes in Patients With Polycystic Ovary Syndrome

detection of gestationalsac, embryonal pole and fetal pulsations by ultrasonography

The weight in kilograms divided by the squared height in meters

The ratio of waist circumference in centimeters to the hip circumference in centimeters

Insulin level in serum after fasting for 8 hours measured as mIU/ml

Free testosterone level in serum measured as ng/dL

total number of ampoules of gonadotrophins

number of cases diagnosed with Ovarian Hyperstimulation Syndrome

number of cases with positive pregnancy test with no clinical pregnancy

presence of two gestational sacs detected by ultrasonography

the presence of gestational sac outside the uterine cavity detected by ultrasound

the number of abortions clinically diagnosed per cycle

labour after 20 weeks of gestation and before completed 37 weeks of gestation

Abdel-Maguid Ramzy

Principal Investigator

Cairo University

Patients will have periodic fasting for 4 weeks prior to the treatment cycle. The fasting method involves daily fasts of 14-16hours and restrict eating to an 8-10 hour "eating window" as 2-3 or more meals of balanced diet. They should take adequate water and non calorie beverages intake daily (2-3 liters)

no fasting, patients will have usual balanced diet as 3 meals and 2 snacks all over the day. They should take adequate water and non calorie beverages intake daily (2-3 liters)

Periodic fasting last for 4weeks prior to the treatment cycle. The fasting method involves daily fasts of 14-16hours and restrict eating to an 8-10 hour "eating window" as 2-3 or more meals of balanced diet. Patients should take adequate water and non calorie beverages intake daily (2-3 liters).

Patients will not fast . But they will take balanced food and drink 2 to 3 liters of water and non caloric drinks all the day for 4 weeks

No fasting

Effect of Fasting on ICSI Outcomes in Poor Responders

number of abortions clinically detected per cycle

Amira S Dieb

Amira S Dieb, MD

Kasr El Aini Hospital

subcutaneous metreleptin injections in one to two daily doses ranging from 0.06 to 0.24 mg/kg per day.

patients with generalized lipodystrophy with subcutaneous metreleptin injection (0.06-0.24 mg/kg/day)

Metreleptin With Generalized Lipodystrophy

patients with partial lipodystrophy with subcutaneous metreleptin injection (0.06-0.24 mg/kg/day)

Metreleptin With Patial Lipodystrophy

Total

Sex: Female, Male

Pediatric patients

Body mass index -standard deviation score (BMI-SDS) represents a measure of weight, adjusted for height, sex, and age. sample range of BMI-SDS is (-3.23, 1.91). Higher value indicates more body fat.

Body mass index-standard deviation score (BMI-SDS)

Percentage body fat

Leptin

Glucose

HbA1c

Fasting insulin

C-peptide

Antidiabetic medications per patient

Insulin users

Lipid-lowering medications per patient

Total cholesterol

Triglycerides

HDL-C

LDL-C

Vitamin A

Vitamin E

25-Hydroxyvitamin D

International Normalized Ratio (INR)

Daily total insulin units per patient

Percentage of glycosylated hemoglobin at Baseline, 6 months, and 12 months on treatment with metreleptin

patients with generalized lipodystrophy (GLD) with initiation of subcutaneous metreleptin injection (0.06-0.24 mg/kg/day)

Generalized Lipodystrophy (GLD)

patients with partial lipodystrophy (PLD) with initiation of subcutaneous metreleptin injection (0.06-0.24 mg/kg/day)

Partial Lipodystrophy (PLD)

Percentage of Glycosylated Hemoglobin at Baseline, 6 Months, and 12 Months on Treatment With Metreleptin

Triglycerides at Baseline, 6 Months, and 12 Months on Treatment With Metreleptin

subcutaneous metreleptin injections in one to two daily doses ranging from 0.06 to 0.24 mg/kg/day.

Metreleptin

Overall Study

Dr. Phillip Gorden

subcutaneous metreleptin injection (0.06-0.24 mg/kg/day)

ovarian cysts/triglyceride

The Effect of Fasting on ICSI Outcomes in Patients With Polycystic Ovary Syndrome

Effect of Fasting on ICSI Outcomes in Poor Responders

Leptin to Treat Lipodystrophy

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