Single-dose, before anesthetic induction:
21.6 mg tetrahydrocannabinol + 20 mg cannabidiol, oromucosal spray.
Dummy 50 ml vial containing 0.9% sodium chloride solution, intravenous.
Prefilled dummy 2ml syringe containing 0.9% sodium chloride solution, intravenous.

Single-dose, before anesthetic induction:
10.8 mg tetrahydrocannabinol + 10 mg cannabidiol, oromucosal spray.
Dummy 50 ml vial containing 0.9% sodium chloride solution, intravenous.
Prefilled dummy 2ml syringe containing 0.9% sodium chloride solution, intravenous.

Single-dose, before anesthetic induction:
Dummy oromucosal spray containing alcohol vehicle without nabiximols.
Prefilled 50 ml vial containing 1 g acetaminophen, intravenous.
Prefilled 2 ml syringe containing 2 mg midazolam, intravenous.

Single-dose, before anesthetic induction:
Dummy oromucosal spray containing alcohol vehicle without nabiximols.
Dummy 50 ml vial containing 0.9% sodium chloride solution, intravenous.
Prefilled dummy 2ml syringe containing 0.9% sodium chloride solution, intravenous.

Pain, Postoperative

Postoperative Nausea and Vomiting

Anxiety

1:1 THC to CBD standardized extract from cannabis plant

Tetrahydrocannabinol

Acetaminophen

Midazolam

Oromucosal spray containing only alcohol vehicle without the active compound (i.e.: without nabiximols)

Dummy oromucosal spray

Hasassah - Hebrew University Ein Kerem Medical Center

Anesthetic Premedication With a Cannabis Extract (Cannapremed)

Effects of a Cannabis Extract as Anaesthetic Premedication on Postoperative Pain, Nausea-vomiting and Perioperative Anxiety

Self-reported visual analog scale (VAS 0 - 100 mm) at rest and on movement. Pre-operative baseline, on arrival to recovery room, after 1 h, before discharge, at 6, 12, and 24 h.

Count of patient-controlled analgesia pushes 1 hour after arrival to the recovery room, before discharge, at 6, and 12.
Total dose of morphine received in 24 hours.

PONV score (0 - 4) on arrival to recovery room, after 1 hour, before discharge, at 6, 12, and 24 hours.
0. No nausea
Nausea sometimes
Nausea most of the time
Dry retching or vomiting
Dry retching or vomiting twice or more

Self-assessed anxiety visual analog scale (0-100 mm) on arrival to the OR; on arrival to and before discharge from recovery room.

Blood sampling from arterial line inserted on arrival to the OR before the main premedication dose, after 30 min, at 1, 3, 6, 12, and 24 hours.

respiratory insufficiency/marihuana

Anesthetic Premedication With a Cannabis Extract (Cannapremed)

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