Metabolic Syndrome

22 Patients will consume 600 mg Alpha lipoic acid for 12 weeks .

Alpha lipoic acid

Participants will be supplemented with 600 mg/day placebo (Starch).

Placebo

Alpha Lipoic Acid Supplementation and Metabolic Syndrome

Assessment of the Effect of Alpha Lipoic Acid Supplementation on Inflammatory Factors, Insulin Resistance, Glycemic Control and Anthropometric Indices in Patients With Metabolic Syndrome

Fasting blood glucose concentration (mg/dl)

Serum TG (triacylglycerol) concentration (mg/dl)

Serum TC (total cholesterol) concentration (mg/dl)

Dr. B.Abbasi

Clinical Professor

In this study, samples will be randomly divided into two groups receiving the supplement or placebo.

This study will be conducted as a parallel randomized double-blind clinical trial. patient will randomly be divided into two groups, each will receive supplement or placebo for 12 weeks .Before the study, containers will be coded as A and B by a person other than the study researchers according the concealment rules .

Individuals with BMI between 30 and 35 kg/m2 will be included in this group and will receive 4 weeks of extra virgin olive oil. Before and after the intervention period data regarding dietary intake and physical activity, brown/beige adipose tissue activity, body composition (DXA), lipid profile and inflammatory markers and brain activity (18F-FDG PET/MRI; in a subsample of 5 obese individuals)will be collected.

Individuals with BMI between 18.5 and 24.99 kg/m2 will be included in this group and will receive 4 weeks of extra virgin olive oil. Before and after the intervention period data regarding dietary intake and physical activity, brown/beige adipose tissue activity, body composition (DXA), lipid profile and inflammatory markers and and brain activity (18F-FDG PET/MRI; in a subsample of 10 normal weight individuals) will be collected.

Obese

2 liters of extra virgin olive oil will be given to participants to include/use in their daily foods.

Extra virgin olive oil

Faculdade de Ciências Médicas Unicamp

Monounsaturated Fatty Acids and Brown/Beige Adipose Tissue in Humans

Effect of Monounsaturated Fatty Acids Consumption in Brown/Beige Adipose Tissue Activity in Human Adults

We will investigate whether 4 weeks of olive oil consumption can increase the activity of brown adipose tissue measured by mean standardized disposal value (volume) using magnetic resonance imaging

To see whether the consumption of 4 weeks of olive oil is able to reduce hypothalamic inflammation in lean and obese individuals as measured by functional resonance imaging

To see whether the consumption of 4 weeks of olive oil is able to reduce LDL and total cholesterol, as well as triglycerides concentrations

To see whether the consumption of 4 weeks of olive oil is able to reduce pro-inflammatory markers (TNF-alpha, interleukin-1beta) and increase interleukin-10

Milena Monfort Pires

LDN, MSc, PhD

University of Campinas, Brazil

University of Sao Paulo

All subjects receive a dietary intervention with olive oil.

Group case: modified ketogenic diet to reduce at least 20% saturated fat, up> 50% of the acid supply monounsaturated, increasing> 50% polyunsaturated fatty acid content and a lower ratio w6 / w3 at least 50% compared to classic diet used by the control group

Epilepsy

Cardiovascular Disease

Non-alcoholic Fatty Liver Disease

Quality of Life

ketogenic diet

Nagila Raquel Teixeira Damasceno

Impact of Ketogenic Diet on Lipoproteins in Refractory Epilepsy

Classic Ketogenic Diet and Modified: Evaluation of the Therapeutic Potential and Impact on the Oxidative Profile, Lipidomic, Inflammatory and Size of Lipoproteins in Children and Adolescents With Refractory Epilepsy

age, income, disease, parent´s education, use of drugs and supplements, type of seizures, questions about quality of life

phase angle mass by impedance bioeletrical

Food record applied during 3 days to each time

Concentration of B-hydroxybutirate in plasma. Determination with kit Ranbut (Randox Laboratories Limited, Reino Unido).

Concentration in plasma. Determination with kit NEFAS(Randox Laboratories Limited, Reino Unido)

saturated fatty acid/martwica

Alpha Lipoic Acid Supplementation and Metabolic Syndrome

Monounsaturated Fatty Acids and Brown/Beige Adipose Tissue in Humans

Impact of Ketogenic Diet on Lipoproteins in Refractory Epilepsy

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