Papulopustular Rosacea

Once daily administration of BPX-04 minocycline gel for 12 weeks

minocycline topical gel

Once daily administration of BPX-04 gel vehicle for 12 weeks

topical gel vehicle

Study Center

Topical Minocycline Gel for Inflammatory Lesions of Papulopustular Rosacea

PRISM: A Double Blind, Randomized, Vehicle Controlled Phase 2 Study to Assess the Safety and Efficacy of BPX-04 Minocycline Topical Gel in the Treatment of Inflammatory Lesions of Papulopustular Rosacea

Change in mean facial inflammatory lesion count

Proportion of subjects with ≥2-point change in IGA of rosacea to clear or almost clear

BioPharmX, Inc.

Vehicle control is identical to the active product in appearance

Transnasal blockade of SPG approach involving the application of 2 cc (approximately the size of a pea) of 2% lidocaine jelly on a cotton swab directed posteriorly towards the SPG in the nasal passage bilaterally. Cotton swab will be inserted to the back of the nasal passage until it can no longer be inserted any further. The cotton swab should remain in place for 15 minutes on both sides simultaneously. The patient will be instructed on how to perform this procedure on themselves, and they will be given supplies for a 7-day supply of medication to be administered two times per day at approximately 12 hour intervals.

Transnasal blockade of SPG approach involving the application of 2 cc (approximately the size of a pea) of nasal saline jelly on a cotton swab directed posteriorly towards the SPG in the nasal passage bilaterally. Cotton swab will be inserted to the back of the nasal passage until it can no longer be inserted any further. The cotton swab should remain in place for 15 minutes. The patient will be instructed on how to perform this procedure on themselves, and they will be given supplies for a 7-day supply of medication to be administered up to two times per day at approximately 12 hour intervals.

Post-Dural Puncture Headache

Patients will be prescribed a regimen of 1 g acetaminophen q 8hrs alternating with 600 mg ibuprofen q 6 hours. In addition they will be instructed to continue oral fluid hydration and minimal activity for 24 hours.
At 2-hours following the SPG blockade an EBP will be offered to patients. Patient will also be informed that they can request an EBP at any time. The SPG blockade will be performed twice daily in the hospital and twice daily at home, by the patient. The patient will also be informed, if that at anytime, they would like an EBP, it can be provided.
While the study is being conducted, patients will not be offered a SPG block unless enrolled in the study.

Lidocaine HCl Gel 2%

placebo gel

University of Utah

RCT of SPG Blocks for Post-dural Headache

A Multicenter Double Blinded Randomized Controlled Trial of the Efficacy of the Sphenopalatine Ganglion Block for the Treatment of the Postdural Puncture Headache After Labor Epidural

Proportion of postpartum women with a postdural puncture headache (PDPH) requesting epidural blood patch (EBP)

Daily Questionnaire regarding functionality

University of Colorado, Denver

University of California, San Francisco

Duke University

Mayo Clinic

Harvard University

Ataxia

Chorea

Dystonia

Parkinsonism

Fatigue

amantadine 5/mg/kg for 2 month- tapered up during 2 weeks at 1 month possibility to increase dosage to 8 mg/kg or reduce it if there are side effects

telangiectasis/ból głowy

Topical Minocycline Gel for Inflammatory Lesions of Papulopustular Rosacea

RCT of SPG Blocks for Post-dural Headache

Amantadine for Improving Neurologic Symptoms in Ataxia-Telangiectasia

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