Patients developing clinical autoimmune encephalitis or meningoencephalomyelitis with anti-GFAP antibodies, managed by the National Reference Center for Paraneoplastic Syndromes and Autoimmune Encephalitis or the National Reference Center for Centre de référence for Neuro-inflammatory diseases of the brain and the spinal cord at the Neurological Hospital of Bron.

Autoimmune GFAP Astrocytopathy

Retrospective, non-interventional study, using clinical, biological, radiological and therapeutic data collected during the initial diagnosis and follow-up.

Description and analysis

Hospices Civils de Lyon

GFAP Auto-immunity : a French Cohort Study

Describe prodromes (yes or no), neurologic signs and clinical course (acute/subacute - yes or
no - or progressive onset - yes or no), if admitted in intensive care units (yes or no), retrospectively provided by
the treating physicians using a structured questionnaire.or progressive onset), if admitted in intensive care units, neoplastic and dysimmune associated diseases and T cell dysregulation condition .

positivity of GFAP α -IgG in cerebrospinal fluid, in serum and isoform type at diagnostic and follow up.
positivity of GFAP α -IgG in cerebrospinal fluid, in serum and isoform type at diagnostic and follow up.

age at onset (years) retrospectively provided by the treating
physicians using a structured questionnaire

Report if caucasian (yes or no) retrospectively provided by the treating
physicians using a structured questionnaire

Report if female sex (yes or no) retrospectively provided by the treating
physicians using a structured questionnaire
physicians using a structured questionnaire

Report if neoplastic and dysimmune associated diseases and T cell dysregulation condition (yes or no)
physicians using a structured questionnaire
physicians using a structured questionnaire

Head and medullar MRI at diagnostic and follow up were reviewed by a neuroradiologist. scale) at each relapse and last follow up.

Describe electroencephalographic results at diagnostic and follow up when done .

Describe electromyographic results at diagnostic and follow up when done .

Describe visual acuity (/10) at diagnostic and follow up when done .

Describe ocular fundus at diagnostic and follow up results when done .

Describe visual field at diagnostic and follow up when done .

Describe optical coherence tomography (RNFL thickness) at diagnostic and follow up when done .

Describe histologic results at diagnostic and follow up when done .

Describe acute and long-term treatments administered and response.

Describe outcome (modified Rankin scale) at each relapse and last follow up.

Retinitis pigmentosa patients with best-corrected visual acuity (BCVA) worse than 20/200 or visual field less than 20 degrees

Retinitis Pigmentosa

One intravitreal injection of a 0.1-ml cell suspension containing around 10x106 bone marrow mononuclear stem cells(BMMSC). All treatments were performed by a single retinal specialist using topical proparacaine drops under sterile conditions (eyelid speculum and povidone-iodine). Autologous BMMSC were injected into the vitreous cavity using a 27 gauge needle inserted through the inferotemporal pars plana 3.0 - 3.5 mm posterior to the limbus. After the injection, central retinal artery perfusion was confirmed with indirect ophthalmoscopy. Patients were instructed to instill one drop of 0.3% ciprofloxacin into the injected eye four times daily for 1 week after the procedure.

intravitreal injection of autologous bone marrow stem cells

Centro de Pesquisa Rubens Siqueira

Autologous Bone Marrow-Derived Stem Cells Transplantation For Retinitis Pigmentosa

Phase 2 Study Of Autologous Bone Marrow-Derived Stem Cells Transplantation For Retinitis Pigmentosa

Rubens Camargo Siqueira

MD,PhD

University of Sao Paulo

open-label study of retinitis pigmentosa patients with best-corrected visual acuity (BCVA) worse than 20/200.

teratoma/obrzęk

GFAP Auto-immunity : a French Cohort Study

Autologous Bone Marrow-Derived Stem Cells Transplantation For Retinitis Pigmentosa

Autologous Bone Marrow-Derived Stem Cells Transplantation For Retinitis Pigmentosa

Najbardziej kompletna baza danych ziół leczniczych poparta naukowo