Each participant will be randomly assigned to one of two treatment groups, low dose of Prednisone 20mg/d (n=10) and high dose of Prednisone 40 mg/d (n=10). During the experimental periods, the subjects will take either one or two 20mg tablet of Prednisone, according to their assigned group. Subjects will be instructed to take the tablets at home in the mornings after a meal each day for 5 consecutive days. At the baseline visit, a medical history will be documented and a physical examination will be performed. Subjects will be asked to come to the research unit on days 1,2,5 after a 14h fasting where two blood samples (5ml each) will be taken, immediately centrifuged, one for biochemical analysis (Lipid profile, Liver function tests, Glucose, Electrolytes and Renal function tests) and the second will be aliquoted, and stored at -20°C until later analyses.

Atherosclerosis

Dyslipidemias

Diabetes

Prednisone 20 Mg

Prednisone 40 Mg

Rambam Health Care Campus

The Effect of Prednisone on Atherogenesis as Studied in the Macrophage Foam Cell Formation Model System.

Macrophage lipids (triglycerides and cholesterol) content (μg/mg cell protein) following incubation with serum derived from the subjects.

Prof. Tony hayek MD

Director, Department of Internal Medicine E

Optical coherence tomography will be performed in all patients

Disorder Related to Cardiac Transplantation

Optical coherence tomography performed during regular coronary angiography

Optical coherence tomography

Helena Bedanova

Michal Pazdernik

Assessment of Cardiac Allograft Vasculopathy by Optical Coherence Tomography

Assessment of Cardiac Allograft Vasculopathy (CAV) by Optical Coherence Tomography (OCT)

OCT imaging will be used for identification of patients with early rapid progression of cardiac allograft vasculopathy. Normalized intimal volume, normalized lumen volume, mean intima thickness and mean intima-to-media ratio (I/M) will be used to identify fast progression of CAV.

Patients with rapid progression of cardiac allograft vasculopathy can be identified by increased titers of donor specific anti-HLA and/or MICA antibodies. Evaluation of anti-HLA antibodies levels (titers) in the serum of a patient is performed by fluorescence intensity of formed complexes. Double laser cytometer Luminex 100 IS 2.3 is used for fluorescence reading.

Tachycardia in heart transplant recipients might represents a risk factor for development of cardiac allograft vasculopathy. Mean heart rate will be measured during 24 hour ECG Holter monitoring, which will evaluate all necessary parameters including its circadian variability.

vasculitis/triglyceride

The Effect of Prednisone on Atherogenesis as Studied in the Macrophage Foam Cell Formation Model System.

Assessment of Cardiac Allograft Vasculopathy by Optical Coherence Tomography

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