Platelet-Rich Plasma vs Corticosteroid Injection as Treatment for Degenerative Pathology of the Temporomandibular Joint
Palavras-chave
Resumo
Descrição
2.0 OBJECTIVES AND PURPOSE
2.1 The purpose of this study is to compare the efficacy, in terms of pain relief and improvement in function, of intra-articular injections with platelet rich plasma versus the current standard which is corticosteroid injections into the temporomandibular joint.
datas
Última verificação: | 02/28/2015 |
Enviado pela primeira vez: | 08/07/2013 |
Inscrição estimada enviada: | 08/08/2013 |
Postado pela primeira vez: | 08/11/2013 |
Última atualização enviada: | 03/09/2015 |
Última atualização postada: | 03/10/2015 |
Data real de início do estudo: | 10/31/2013 |
Data Estimada de Conclusão Primária: | 10/31/2013 |
Condição ou doença
Intervenção / tratamento
Drug: Group A (corticosteroid injection group)
Biological: Group B (platelet rich plasma injection)
Fase
Grupos de Armas
Braço | Intervenção / tratamento |
---|---|
Active Comparator: Group A (corticosteroid injection group) Group A will receive one intra-articular injection of 2 ml of solution containing 1ml of 10mg/ml Triamcinolone suspended in 1 ml of 0.5% Bupivacaine solution per affected joint | Drug: Group A (corticosteroid injection group) |
Experimental: Group B (platelet rich plasma injection) Group B will receive a 2 ml intra-articular injection of a platelet rich plasma preparation per affected joint | Biological: Group B (platelet rich plasma injection) |
Critério de eleição
Sexos elegíveis para estudo | All |
Aceita Voluntários Saudáveis | sim |
Critério | Inclusion Criteria: The following diagnostic criteria for patient selection are to be used: - Patients will need to have a history of chronic pain (at least 3 months) refractory to conservative therapy with non-steroidal anti-inflammatory medications, muscle relaxants, diet modifications and splint therapy - Patients will also need to have imaging findings (radiography or magnetic resonance imaging) that show mild to severe degenerative changes of the temporomandibular joint Exclusion Criteria: Exclusion criteria will include - Patients with systemic disorders such as rheumatic diseases, hematologic diseases, active infections, immunosuppression - Patients receiving therapy with anticoagulants |
Resultado
Medidas de Resultado Primário
1. Pain relief [24 weeks]
Medidas de Resultado Secundário
1. Improvement in function [24 weeks]