Planta Medica 2012-Oct
Antiviral triterpenoid saponins from the roots of Ilex asprella.
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Two new sulfur-containing triterpenoid saponins, asprellanosides A (1) and B (2), were isolated from the roots of Ilex asprella, together with 10 known compounds (3-12). An in vitro anti-HSV-1 activity test of the isolates (1-4, 6-7, and 9-12) showed that only asprellanoside A (1) and oblonganoside H (6) exhibited anti-HSV-1 activity with TIC values of 0.14 and 0.18 mM, respectively.