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Farmakologiia i toksikologiia

[Changes in the alanine aminotransferase and alkaline phosphatase activity and the bilirubin content under the action of spermaceti oil, corn oil and fish oil].

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S I Budantseva

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Effect of spermaceti oil, cod-liver oil and corn oil on the content of total, direct and indirect bilirubin, on the activity of transaminase, alkaline phosphatase and colloid resistance was studied in three animal species (rabbits, guinea-pigs and albino rats) during 120 days (90 days of administration and 30 days of after-effect). Histological examination was performed on a selective basis with the use of hematoxylin eosin staining. Use was made of MacManus technique to reveal neutral polysaccharides, glycogen and lipids. It has been shown that the test oils exert largely consistent effects on renal function, the degree of these effects being dose-dependent.

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