[Changes in the neurons of the spinal cord and spinal ganglia in hypokinesia (a neuromorphological and histochemical study)].

On 62 white male rats at hypokinesia lasting for 7-60 days, motoneurons and neural cells of the lumbar sensitive ganglia have been studied at the level of L2--L4. Certain changes in the spinal ganglia have been neurohistologically revealed beginning from the 30th day of the experiment. In most of the neurons, mainly in large ones, phenomena of central chromatolysis are observed. In one-third of the cells, nuclear hyperchromatosis of various intensity is noted. As the experiment proceeds, the changes acquire a well developed character. In the spinal motoneurons, on the 30th-45th day of the experiment, peripheral chromatolysis, moderate nuclear hyperchromatosis nuclear hypertrophy are detected. Satellite neuroglia is increased according to the "Umklammerying" phenomenon. Cytophotometric investigation of SDG, NAD-D and AF demonstrates certain discoordination in their activity. On the 7th day, SDG and NAD-D activity in the spinal ganglia increases. Beginning from the 30th day, SDG and NAD-D activity in the objects studied decreases, while that of LDG and AF increases. Hypoxia is suggested to be the cause of the disorders observed. A supposition is made that the high AF activity could result in the disturbed activity of the enzymes localizing in mitochondria.