Continued therapy with HIV-1 protease inhibitors, despite previous hypersensitivity reactions, through coadministration of prednisone.

We describe an HIV-1 positive patient who developed severe hypersensitivity reactions during treatment with each of the three currently available protease inhibitors. Addition of prednisone enabled continued use of saquinavir, one of these protease inhibitors, thereby achieving a degree of viral suppression which otherwise would not have been possible.