Etoricoxib inhibits peripheral inflammation and alters immune responses in intracerebroventricular colchicine injected rats.

The present study was designed to investigate the effectiveness of etoricoxib induced inhibition of neuroinflammation by studying the peripheral inflammatory markers and select immune parameters in intracerebroventricular colchicine injected rats (ICIR). Results showed time dependent upregulation of the inflammatory markers in the serum along with alterations of peripheral immune parameters in ICIR and dose-dependent recovery was observed upon administration of etoricoxib to ICIR; most of these effects were greater with the longer duration of study. The present study indicates that colchicine induced neuroinflammation may cause systemic inflammation and alteration of immune responses which are mediated by increased cox- 2 activity.