Modulating effect of Gmelina arborea Linn. on immunosuppressed albino rats.
Palavras-chave
Resumo
OBJECTIVE
In the present study, the immunomodulatory effects of roots of Gmelina arborea Linn. were investigated
METHODS
Methanolic extract of G. arborea Linn. (MEGA) and its ethyl acetate fraction (EAFME) were used for evaluating the pharmacological activity. The modulating effect was evaluated on humoral and cell-mediated immune response using animal models like cyclophosphamide-induced myelosuppression, delayed-type hypersensitivity (DTH) response, and humoral antibody (HA) titre
RESULTS
Both test extracts produced significant increase in HA titre, DTH response, and levels of total white blood cell count
CONCLUSIONS
This drug is found to be a potential immunostimulant.