Somnolence syndrome and fever in pediatric patients with cranial irradiation.
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Resumo
BACKGROUND
During initial treatments, pediatric cancer patients are frequently hospitalized for fever, which may be due to neutropenia or a manifestation of the somnolence syndrome (SS) after cranial radiation therapy (CRT). This was a retrospective chart review of patients who received CRT for central nervous system prophylaxis or treatment in acute lymphoblastic leukemia or lymphoma.
METHODS
Of 21 patients, 15 (71%) developed SS; 10 were hospitalized for fever. Comparing somnolent and nonsomnolent patients, there was no statistically significant difference in the admission absolute neutrophil count; radiation dose, fraction, or duration; and time between completion of CRT and first hospitalization.
CONCLUSIONS
In postradiation phase, patients with SS are more likely to get fever leading to hospital admission regardless of ANC.
