In a repeated measures design, 50 adult male and female exclusive WP smokers will smoke WP tobacco weekly over a 3-week study period with 3 WP smoking practices.

A total of 25 adult make and female nonsmokers will be recruited as a control.

Waterpipe Smoking

In a repeated measures design, 50 adult male and female exclusive WP tobacco smokers will smoke WP tobacco weekly over a 3-week study period with 3 WP smoking practices as follows: 1) using room temperature water in the WP jar, 2) adding ice cubes to the water in the WP jar, and 3) using a charcoal-free electronic WP head to heat the tobacco. Six Spot first morning urine samples will be provided by participants. Two urine samples per each of the 3 smoking sessions. Urine samples will be provided on the day of the WP tobacco smoking session and the following day. Physiological measures will be taken at Baseline during the office visit and before and after each of the 3 WP tobacco smoking sessions.

Waterpipe smoking

Center for Behavioral Epidemiology and Community Health

Assessing Toxicity of Waterpipe Tobacco Smoking

Assessing Toxicity of Waterpipe Tobacco Smoking in Laboratory and Naturalistic Settings

The investigators will assess change in urinary levels of cotinine in ng/ml and ng/mg creatinine, which is the metabolite of the addictive drug nicotine, post each of three waterpipe tobacco smoking sessions. For each of the three smoking sessions, smokers will provide two first morning spot urine samples, the day of the smoking session and the following morning. The three waterpipe tobacco smoking sessions are as follows: 1) using room temperature water in the waterpipe jar, 2) adding ice cubes to the water in the waterpipe jar, and 3) using a charcoal-free electronic waterpipe head to heat the tobacco instead of charcoal.

The investigators will assess change in urinary levels of NNAL in pg/ml and ng/mg creatinine, which is the metabolite of NNK, a tobacco specific pulmonary carcinogen, post each of three waterpipe tobacco smoking sessions. For each of the three smoking sessions, smokers will provide two first morning spot urine samples, the day of the smoking session and the following morning. The three waterpipe tobacco smoking sessions are as follows: 1) using room temperature water in the waterpipe jar, 2) adding ice cubes to the water in the waterpipe jar, and 3) using a charcoal-free electronic waterpipe head to heat the tobacco instead of charcoal.

The investigators will assess change in urinary levels of SPMA in pmol/ml and pmol/mg creatinine, which is the metabolite of benzene, the human hematotoxicant and leukemogen, post each of three waterpipe tobacco smoking sessions. For each of the three smoking sessions, smokers will provide two first morning spot urine samples, the day of the smoking session and the following morning. The three waterpipe tobacco smoking sessions are as follows: 1) using room temperature water in the waterpipe jar, 2) adding ice cubes to the water in the waterpipe jar, and 3) using a charcoal-free electronic waterpipe head to heat the tobacco instead of charcoal.

The investigators will assess change in urinary levels of 1-HOP in pmol/ml and pmol/mg creatinine, which is the metabolite of pyrene, a genotoxic carcinogen, post each of three waterpipe tobacco smoking sessions. For each of the three smoking sessions, smokers will provide two first morning spot urine samples, the day of the smoking session and the following morning. The three waterpipe tobacco smoking sessions are as follows: 1) using room temperature water in the waterpipe jar, 2) adding ice cubes to the water in the waterpipe jar, and 3) using a charcoal-free electronic waterpipe head to heat the tobacco instead of charcoal.

The investigators will determine the differential effects of 3 waterpipe smoking practices on carbon monoxide (CO) exposure. We will measure breath CO using a Micro+ Smokerlyzer® CO monitor for exhaled CO before and after each of the 3 WP smoking sessions as follows: 1) using room temperature water in the WP jar, 2) adding ice cubes to the water in the WP jar, and 3) using a charcoal-free electronic WP head to heat the tobacco.

The investigators will investigate the differential effects of WP smoking practices on pulmonary function tests and respiratory symptoms by measuring blood oxygen saturation (SO2), and conducting pulmonary functions (PF) testing using a portable spirometer/oximeter to determine the change in forced expiratory volume (FEV1), forced vital capacity (FVC), FEV1/FVC and Forced Expiratory Flow (FEF25-75%) post each of the 3 waterpipe tobacco smoking sessions as follows: 1) using room temperature water in the WP jar, 2) adding ice cubes to the water in the WP jar, and 3) using a charcoal-free electronic WP head to heat the tobacco.

The investigators will investigate the differential effects of WP smoking practices on the cardiovascular system by measuring the change in blood pressure in mm/Hg, heart rate in beats/minute, and respiratory rate in number of breaths/minute, after each of the 3 WP smoking sessions as follows: 1) using room temperature water in the WP jar, 2) adding ice cubes to the water in the WP jar, and 3) using a charcoal-free electronic WP head to heat the tobacco.

The investigators will assess change in urinary levels of Furan-BDA-NAL in pmol/ml and pmol/mg creatinine, which is the metabolite of furan, a liver toxicant and carcinogen, post the first waterpipe tobacco smoking session. Furan-BDA-NAL will be assessed in the provide two first morning spot urine samples, the day of the first smoking session and the day following the first smoking session.

Nada Kassem

San Diego State University

The investigators will employ a repeated measures design. A sample of 50 adult male and female exclusive WP smokers and a control sample of 25 male and female non-smokers will be recruited. Over a 3-week study, WP smokers will smoke one WP tobacco head during each of 3 separate WP smoking sessions with a 7-day washout period before each session. Session 1, WP smokers will smoke using 1 quick-light charcoal and room temperature water in the WP jar; Session 2, WP smokers will smoke using 1 quick-light charcoal but adding ice cubes to the water in the WP jar; Session 3, WP smokers will smoke WP tobacco without charcoal using an electric WP head and room temperature water. Physiological effects, carbon monoxide exposure and biomarkers of toxicants and carcinogens related to WP tobacco smoking practices will be compared.

1 butanol/náusea

Assessing Toxicity of Waterpipe Tobacco Smoking

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