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9 resultados
Inhibition of key enzymes linked to type 2 diabetes by compounds isolated from Aframomum melegueta fruit.
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BACKGROUND
The use of Aframomum melegueta K. Schum. (Zingiberaceae) fruit for treatment of diabetes has recently been established in Nigeria. However, compounds responsible for the antidiabetic action have not been identified.
OBJECTIVE
The present study carried out the bioassay-guided isolation of
Two undescribed paradol-related specialized metabolites from Aframomum melegueta.
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Aframomum melegueta seeds are widely used as a spice in Africa. Two undescribed paradol-related compounds, (S)-9-hydroxy-[6]-paradol (1) and (9S)-3,9-dihydroxydihydro-[6]-paradol (2) together with eight reported constituents (3-10) were isolated and
Putative mycobacterial efflux inhibitors from the seeds of Aframomum melegueta.
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In order to identify new putative efflux pump inhibitors that represent an appropriate target in antimycobacterial chemotherapy, nine paradol- and gingerol-related compounds (1-9) isolated from the seeds of Aframomum melegueta were assessed for their potential to inhibit ethidium bromide (EtBr)
Anti-adhesive activity of Aframomum melegueta major phenolics on lower respiratory tract pathogens.
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Recent studies have raised interest in the potential health effect of Aframomum melegueta, which is related to the phenolic content of its seeds. The methanolic extract of A. melegueta seeds showed a significant anti-adhesive effect against Staphylococcus aureus to lung carcinoma cell line in a
Anti-inflammatory activity of grains of paradise (Aframomum melegueta Schum) extract.
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The ethanolic extract of grains of paradise (Aframomum melegueta Schum, Zingiberaceae) has been evaluated for inhibitory activity on cyclooxygenase-2 (COX-2) enzyme, in vivo for the anti-inflammatory activity and expression of several pro-inflammatory genes. Bioactivity-guided fractionation showed
Grains of paradise (Aframomum melegueta) extract activates brown adipose tissue and increases whole-body energy expenditure in men.
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Brown adipose tissue (BAT) is responsible for cold- and diet-induced thermogenesis, and thereby contributes to the control of whole-body energy expenditure (EE) and body fat content. BAT activity can be assessed by fluoro-2-deoxyglucose (FDG)-positron emission tomography (PET) in human subjects.
Compounds from Sichuan and Melegueta peppers activate, covalently and non-covalently, TRPA1 and TRPV1 channels.
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OBJECTIVE
Oily extracts of Sichuan and Melegueta peppers evoke pungent sensations mediated by different alkylamides [mainly hydroxy-alpha-sanshool (alpha-SOH)] and hydroxyarylalkanones (6-shogaol and 6-paradol). We assessed how transient receptor potential ankyrin 1 (TRPA1) and TRP vanilloid 1
Phenolics Isolated from Aframomum meleguta Enhance Proliferation and Ossification Markers in Bone Cells.
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Osteoporosis is a serious health problem characterized by decreased bone mineral density and deterioration of bone microarchitecture. Current antiosteoporotic agents exhibit a wide range of adverse effects; meanwhile, phytochemicals are effective and safer alternatives. In the current work, nine
Identification of vanilloid compounds in grains of paradise and their effects on sympathetic nerve activity.
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BACKGROUND
Grains of paradise (GP) is the seed of Aframomum melegueta, which is widely distributed throughout West Africa and has been used as a spice and a folk remedy for a long time. Anti-obesity effect of GP intake was demonstrated in a previous report. Aim of the present study was to isolate
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