Treatment consistsof Mesenchymal Stem Cells administered as a one-time, single-dose therapy via IV infusion at a dose of 1 X 10 8 cells.

ARDS, Human

Covid-19

Mesenchymal Stem Cells as a single-dose therapy via IV infusion at a dose of 1 X 10 8 cells.

Mesenchymal Stem Cells derived from Wharton Jelly of Umbilical cords

Instituto de Medicina Regenerativa

Use of Mesenchymal Stem Cells in Acute Respiratory Distress Syndrome Caused by COVID-19

A Study of Mesenchymal Stem Cells as a Treatment in Patients With Acute Respiratory Distress Syndrome Caused by COVID-19

Number of patients with changes in percentage of resting Oxygen saturation (%O2)

Changes in mmHg of Arterial partial pressure of oxygen / Fraction of inspiration O2 (PaO2/FiO2) in all participants

Changes in percentage of participants with reduction in bilateral ground-glass opacities

Changes in percentage of participants with reduction of pneumonia bilateral infiltration

Number of participants with a reduction in Lactate dehydrogenase (mg/dL)

Number of participants with a reduction in C-reactive protein (mg/dL)

Number of participants with a reduction in D-dimer (mg/dL)

Number of participants with a reduction in Ferritine (mg/dL)

Subjects in the siltuximab group will receive an 11 mg/kg infusion at baseline, and weeks 3 and 6, as per the recommended dosing for multicentric Castleman's disease

Subjects in the placebo group will receive an infusion of normal saline (with the same packaging and volume as the siltuximab group) at baseline, and weeks 3 and 6.

Schizophrenia

Psychotic Disorders

Siltuximab

normal saline

Augusta University

Siltuximab in Schizophrenia

A Randomized Controlled Trial of Adjunctive Siltuximab in Schizophrenia

The Brief Assessment of Cognition in Schizophrenia (BACS) is the metric used to characterize cognition in this study. The BACS consists of 6 subscales: Verbal Memory (range 0-75), Working Memory (range 0-28), Motor Speed (range 0-100), Verbal Fluency (measure is total number of words generated in two 60 second trials), Attention and Processing speed (range 0-110), and Executive Function (range 0-22). For each subscale, higher scores reflect better cognition. For each subscale, a Standard Deviation Score was calculated based on normative data (Keefe et al. Norms and standardization of the Brief Assessment of Cognition in Schizophrenia (BACS). Schizophrenia Research 102 (2008) 108-115). The BACS composite score is calculated as the average Standard Deviation Score of the 6 subscale scores. The change in BACS composite score will be calculated as the BACS composite score at 9 weeks minus the BACS composite score at baseline.

The Positive and Negative Symptoms Scale (PANSS) is the metric used to characterize psychotic symptoms in this study. The PANSS consists of 30 items, each scored 1-7. The range for the PANSS total score is 30-210. There are 3 subscales - PANSS positive score (range 7-49), PANSS negative score (range 7-49), and PANSS general score (range 16-112). PANSS total score is the summation of these 3 subscales. Higher values for the total and subscale scores reflect more severe psychopathology. A positive change in PANSS total score reflects an increase in psychopathology. A negative change in PANSS total score reflects a decrease in psychopathology.

adenine/diarreia

Use of Mesenchymal Stem Cells in Acute Respiratory Distress Syndrome Caused by COVID-19

Siltuximab in Schizophrenia

O mais completo banco de dados de ervas medicinais apoiado pela ciência