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9 resultados
Adenosine A2B receptor antagonists
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The present invention relates to 8-pyrazol-xanthine derivatives, pharmaceutical compositions containing them, and methods of treating conditions and diseases mediated by the adenosine A.sub.2B receptor activity, by employing such compounds.
Accordingly, the present invention provides compounds of
Method for treating retinal degeneration with purinergic receptor agonists
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TECHNICAL FIELD
The present invention relates to a method of protecting or delaying retinal neurons from cell death by administering purinergic receptor agonists such as uridine 5'-di-and triphosphates, cytidine 5'-di-and triphosphates, dinucleoside polyphosphates, and their analogs
Fused tricyclic compounds as adenosine receptor antagonist
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TECHNICAL FIELD
The present disclosure relates to a series of substituted fused tricyclic compounds, their tautomers, polymorphs, stereoisomers, prodrugs, solvates, pharmaceutically acceptable salts, pharmaceutical compositions containing them and methods of treating conditions and diseases that are
Formulations for reducing neuronal degeneration
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TECHNICAL FIELD
This invention relates to treatment of neurodegenerative disorders, and more particularly to Alzheimer's disease and Parkinson's disease.
BACKGROUND
Oxidative stress plays a role in neurodegeneration, regardless of etiology. Physical trauma or secondary effects of insult to the
4-quinolinemethanol derivatives as purine receptor antagonists (II)
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This application is a 371 of PCT/GB99/02924 filed Sep. 3, 1999.
The present invention relates to 4-quinolderivnatives and their use in therapy. In particular, the present invention relates to the treatment of disorders in which the reduction of purinergic neurotransmission could be beneficial. The
PARP inhibitors
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FIELD OF THE INVENTION
The present invention relates to new inhibitors of the nucleic enzyme poly(adenosine 5'-diphospho-ribose) polymerase ["poly(ADP-ribose) polymerase" or "PARP", which is also sometimes called "PARS" for poly(ADP-ribose) synthetase]. More particularly, the invention relates to
4-Quinolinemethanol derivatives as purine receptor antagonists (1)
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The present invention relates to 4-quinolinylmethanol derivatives and their use in therapy. In particular, the present invention relates to the treatment of disorders in which the reduction of purinergic neurotransmission could be beneficial. The invention relates in particular to adenosine
Methods and compositions for treating osteoarthritis and promoting cartilage formation
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FIELD OF THE INVENTION
The present invention relates to methods and compositions for inhibiting and treating osteoarthritis and for promoting cartilage formation, particularly liposomes and liposomal compositions containing an adenosine receptor agonist, or an analog or derivative thereof or a
Tricyclic fused pyrimidine derivatives, their production and use
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BACKGROUND OF THE INVENTION
This invention relates to novel tricyclic fused pyrimidine derivatives useful as medicines
Pyrazolo[3,4-d]pyrimidine derivatives having, among others, analgesic, antiinflammatory and diuretic actions are disclosed in Japanese Unexamined Patent Publication No. 31694/1978,
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