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Página 1 a partir de 72 resultados
Arrest and killing of tumor cells by adenosine 5-diphosphate and adenosine-5-triphosphate
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BACKGROUND OF THE INVENTION
This invention relates to the use of adenosine 5'-diphosphate (ADP) and/or adenosine 5'-triphosphate (ATP) for selective inhibition of growth and subsequent killing of malignant cells, e.g., human malignant cells, thereby utilizing a normal metabolite for inhibiting,
Agonists of A.sub.2A adenosine receptors for treating recurrent tumor growth
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FIELD OF THE INVENTION
The present invention relates to a method for treating recurrent tumor metastases following liver resection that includes administration of an effective amount of an agonist of A.sub.2A adenosine receptors (ARs).
BACKGROUND OF THE INVENTION
In the United States, approximately
Methods of inhibiting tumor growth using adenosine receptor activated cells
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FIELD OF THE INVENTION
The present invention relates to methods of treating and or imaging tumors, and particularly to methods of treating and/or imaging tumors using A.sub.1 adenosine-receptor activated cells, such as monocytes, macrophages and/or splenocytes.
BACKGROUND OF THE INVENTION
Purinergic
Aristeromycin analogues of 4',5'-didehydro-5'-fluoro-adenosine and methods of treating neoplastic and viral disease conditions
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BACKGROUND OF THE INVENTION
S-Adenosyl-L-methionine (AdoMet) dependent transmethylation reactions have been implicated in a variety of biological processes related to vital growth and replication, vital transformation of cells, growth of malignant cells, and processes such as chemotaxis and
Method and compositions for treating and diagnosing tumors using adenosine receptor activated cells
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FIELD OF THE INVENTION
The present invention relates to methods of treating and or imaging tumors, and particularly to methods of treating and/or imaging tumors using A.sub.1 adenosine-receptor activated cells, such as monocytes, macrophages and/or splenocytes.
BACKGROUND OF THE INVENTION
Purinergic
Use of adenosine aspartate for the preparation of pharmaceutical products for the treatment of liver cancer
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CROSS-REFERENCES TO RELATED APPLICATIONS
This application is the National Stage of International Application No. PCT/MX2008/000111, filed Aug. 21, 2008, and which claims priority of Mexican Patent Application No. MX/a/2007/010896, filed Sep. 6, 2007.
FIELD OF THE INVENTION
The present invention
Combination cancer therapy comprising adenosine and deaminase enzyme inhibitors
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FIELD OF THE INVENTION
The present invention relates generally to the field of medicine. More particularly, the invention relates to the field of oncology, especially the treatment of cancers of an epithelial origin.
DESCRIPTION OF RELATED ART
Purine nucleosides (e.g., adenosine, deoxyadenosine,
Use of adenosine A3 receptor antagonists to inhibit tumor growth
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FIELD OF THE INVENTION
The present invention relates to the use of adenosine A.sub.3 receptor antagonists to inhibit the growth of tumors.
BACKGROUND OF THE INVENTION
Traditional anti-tumor therapy has employed cytotoxic agents, such as cis-platin, vinblastine, daunorubicin, and doxorubicin, to
Method of preparing adenosine-resistant anti-tumor T lymphocytes for adoptive immunotherapy
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3. BACKGROUND
Cancer is one of the most serious health concerns in the developed world, and new strategies for fighting cancer are necessary. One promising technique is adoptive immunotherapy, in which immune cells are transplanted into a cancer patient in order to stimulate immune rejection of the
Microparticle formulations of adenosine receptor antagonists for treating cancer
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INTRODUCTION
Immunotherapy is rapidly emerging as a cancer treatment with high potential. Recent advances in immune checkpoint therapy have led to the FDA approval and successful launch of several products in treating various cancers. These new drug products are based on the blocking of the
2' and/or 5' amino-acid ester phosphoramidate 3'-deoxy adenosine derivatives as anti- cancer compounds
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RELATED APPLICATIONS
This application is a .sctn. 371 national stage application based on Patent Cooperation Treaty Application serial number PCT/GB2015/053628, filed Nov. 27, 2015; which claims the benefit of priority to GB 1421211.2, filed Nov. 28, 2014; and GB 1519316.2, filed Nov. 2, 2015.
The
Adenosine diphosphoribose polymerase binding nitroso aromatic compound useful as retroviral inactivating agents, anti-retroviral agents and anti-tumor agents
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FIELD OF THE INVENTION
The present invention relates generally to the field of retroviral therapeutic and inactivating agents and their use in treating retroviral infections and cancers. More specifically it relates to those therapeutic and inactivating C-nitroso compounds which destabilize zinc
Adenosine diphosphoribose polymerase binding nitroso aromatic compounds useful as retroviral inactivating agents, anti-retroviral agents and anti-tumor agents
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FIELD OF THE INVENTION
The present invention relates generally to the field of retroviral therapeutic and inactivating agents and their use in treating retroviral infections and cancers. More specifically it relates to those therapeutic and inactivating C-nitroso compounds which destabilize zinc
Adenosine diphosphoribose polymerase binding nitroso aromatic compounds useful as retroviral inactivating agents, anti-retroviral agents and anti-tumor agents-54
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FIELD OF THE INVENTION
The present invention relates generally to the field of retroviral therapeutic and inactivating agents and their use in treating retroviral infections and cancers. More specifically it relates to those therapeutic and inactivating C-nitroso compounds which destabilize zinc
Adenosine diphosphoribose polymerase binding nitroso aromatic compounds useful as retroviral inactivating agents, anti-retroviral agents, anti-retroviral agents and anti-tumor agents
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FIELD OF THE INVENTION
The present invention relates generally to the field of retroviral therapeutic and inactivating agents and their use in treating retroviral infections and cancers. More specifically it relates to those therapeutic and inactivating C-nitroso compounds which destabilize zinc
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