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This invention is concerned with the use of adenosine as an agent for the treatment of human beings. More particularly, this invention is concerned with the administration of adenosine to human patients by continuous intravenous infusion for, inter alia, control of blood pressure, use as a selective
FIELD OF THE INVENTION
The present invention relates to novel compounds that are partial or full A.sub.1 adenosine receptor agonists, and to their use in treating mammals for various disease states, including modifying cardiac activity, in particular treatment of arrhythmia. The compounds are also
FIELD OF THE INVENTION
The present invention relates to a method for promoting the growth of new blood vessels (angiogenesis) especially coronary blood vessels after myocardial infarction.
BACKGROUND OF THE INVENTION
It is estimated that five million people are afflicted with chronic stable angina
FIELD OF THE INVENTION
The present invention relates to novel compounds that are A.sub.1 adenosine receptor agonists, and to their use in treating mammals for various disease states, including modifying cardiac activity, in particular treatment of arrhythmia. The compounds are also useful for
FIELD OF THE INVENTION
The present invention relates to novel compounds that are partial or full A.sub.1 adenosine receptor agonists, and to their use in treating mammals for various disease states, including modifying cardiac activity, in particular treatment of arrhythmia. The compounds are also
FIELD OF THE INVENTION
The present invention relates to the preparation of compounds that are partial or full A.sub.1 adenosine receptor agonists. The compounds are useful for treating mammals with diabetic disorders, obesity, modifying adipocyte function, CNS disorders, and modifying cardiac
FIELD OF THE INVENTION
The present invention relates to novel compounds that are partial or full A.sub.1 adenosine receptor agonists, and to their use in treating mammals for various disease states, including modifying cardiac activity, in particular treatment of arrhythmia. The compounds are also
The present invention relates to 2-aminothiophene derivatives, pharmaceutical compositions containing them, and to methods of treating conditions mediated by the A.sub.1 adenosine receptor including pain, in particular, chronic pain such as neuropathic pain, cardiac disease or disorder such as
The present invention relates to 2-aminothiophene derivatives, pharmaceutical compositions containing them, and to methods of treating conditions mediated by the A.sub.1 adenosine receptor including pain, in particular, chronic pain such as neuropathic pain, cardiac disease or disorder such as
FIELD OF THE INVENTION
The present invention relates to the preparation of compounds that are partial or full A.sub.1 adenosine receptor agonists. The compounds are useful for treating mammals with diabetic disorders, obesity, modifying adipocyte function, CNS disorders, and modifying cardiac
FIELD OF THE INVENTION
The present invention relates to novel compounds that are partial or full A.sub.1 adenosine receptor agonists, and to their use in treating mammals for various disease states, including modifying cardiac activity, in particular treatment of arrhythmia. The compounds are also
FIELD OF THE INVENTION
The present invention relates to novel compounds that are partial or full A.sub.1 adenosine receptor agonists, and to their use in treating mammals for various disease states, including modifying cardiac activity, in particular treatment of arrhythmia. The compounds are also
FIELD OF THE INVENTION
The present invention relates to novel compounds that are partial or full A.sub.1 adenosine receptor agonists, and to their use in treating mammals for various disease states, including cardiovascular diseases, in particular arrhythmia, and the prevention of sudden death
FIELD OF THE INVENTION
This invention relates to compounds derived from 4-anilinoquinazolines that present adenosine-kinase inhibitory activity and use thereof in diseases or conditions that are benefited from the adenosine kinase inhibition. More particularly, the present invention relates to the
FIELD OF THE INVENTION
The present invention relates to novel compounds that are partial or full A.sub.1 adenosine receptor agonists, and to their use in treating mammals for various disease states, including cardiovascular diseases, in particular arrhythmia, and the prevention of sudden death