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Página 1 a partir de 16 resultados
Methods, pharmaceutical and therapeutic compostions for administering adenosine
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FIELD OF THE INVENTION
The invention relates to the chronic elevation of endogenous adenosine levels by the use of stable adenosine 5'-triphosphate (ATP) compositions, which are taken orally over a period of time. The elevated levels of adenosine, produced by the in vivo degradation of ATP, act in
N6 heterocyclic 5' modified adenosine derivatives
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BACKGROUND OF THE INVENTION
(1) Field of the Invention
There is provided useful drugs and pro-drugs that are N.sup.6 heterocyclic 5' modified adenosine derivatives. The compositions of this invention are selective, partial or full adenosine A.sub.1 receptor agonists, and as such, are useful for
N6 heterocyclic 8-modified adenosine derivatives
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BACKGROUND OF THE INVENTION
(1) Field of the Invention
There is provided useful drugs and pro-drugs that are N.sup.6 heterocyclic 8 modified adenosine derivatives. The compositions of this invention are selective, partial or full adenosine A.sub.1 receptor agonists, and as such, are useful for
Partial or full A1agonists-N-6 heterocyclic 5'-thio substituted adenosine derivatives
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BACKGROUND OF THE INVENTION
(1) Field of the Invention
This invention includes stable and useful drugs and pro-drugs that are N.sup.6 heterocyclic 5'-thio modified adenosine derivatives. The compositions of this invention are selective, partial or full adenosine A.sub.1 receptor agonists, and as
Partial and full agonists A.sub.1 adenosine receptors
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FIELD OF THE INVENTION
The present invention relates to novel compounds that are partial or full A.sub.1 adenosine receptor agonists, and to their use in treating mammals for various disease states, including modifying cardiac activity, in particular treatment of arrhythmia. The compounds are also
Partial and full agonists of A.sub.1 adenosine receptors
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FIELD OF THE INVENTION
The present invention relates to novel compounds that are partial or full A.sub.1 adenosine receptor agonists, and to their use in treating mammals for various disease states, including modifying cardiac activity, in particular treatment of arrhythmia. The compounds are also
Substituted bicyclic and tricyclic thieno[2,3-d]pyrimidines as A.sub.2A adenosine receptor antagonists
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FIELD OF THE INVENTION
The present invention relates to novel compounds that are A.sub.2A adenosine receptor antagonists, and to their use in treating mammals for various disease states, such as obesity, CNS disorders, including the "movement disorders" (Parkinson's disease, Huntington's Chorea, and
Use of compounds extracted from Momordica charantia L. in the manufacture of medicaments for prevention and treatment of diabetes and obesity
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CROSS-REFERENCE TO RELATED APPLICATIONS
This application is a National Stage of International Patent Application No. PCT/CN2009/000050, filed on Jan. 14, 2009, which claims priority to foreign Patent Application No. CN 2008 10033348.5, filed on Jan. 31, 2008, the disclosures of which are
Methods of using AMPD2 inhibitors for the treatment of fatty liver, obesity and diabetes
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FIELD OF THE INVENTION
The present invention relates to adenosine monophosphate deaminase (AMPD) modulators and methods for using the same to treat a clinical condition associated with the metabolic syndrome. In particular, methods of the invention relate to administering a compound or a composition
Purine derivatives as adenosine A1 receptor agonists and methods of use thereof
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1. FIELD OF THE INVENTION
The invention relates to Purine Derivatives; compositions comprising an effective amount of a Purine Derivative; and methods for reducing an animal's rate of metabolism, protecting an animal's heart against myocardial damage during cardioplegia; or for treating or
Purine derivatives as adenosine A.sub.1 receptor agonists and methods of use thereof
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1. FIELD OF THE INVENTION
The invention relates to Purine Derivatives; compositions comprising an effective amount of a Purine Derivative; and methods for reducing an animal's rate of metabolism, protecting an animal's heart against myocardial damage during cardioplegia; or for treating or
Purine Derivatives as adenosine A.sub.1 receptor agonists and methods of use thereof
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1. FIELD OF THE INVENTION
The invention relates to Purine Derivatives; compositions comprising an effective amount of a Purine Derivative; and methods for reducing an animal's rate of metabolism, protecting an animal's heart against myocardial damage during cardioplegia; or for treating or
Substituted fused pyrimidine compounds
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FIELD OF THE INVENTION
The present invention relates to a series of novel substituted fused pyrimidine compounds, their tautomers, polymorphs, stereoisomers, prodrugs, solvates, pharmaceutically acceptable salts, pharmaceutical compositions containing them and methods of treating conditions and
Substituted fused pyrimidine compounds
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FIELD OF THE INVENTION
The present invention relates to a series of novel substituted fused pyrimidine compounds, their tautomers, polymorphs, stereoisomers, prodrugs, solvates, pharmaceutically acceptable salts, pharmaceutical compositions containing them and methods of treating conditions and
Method for treatment of hyperglycemia and hyperlipidemia
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CROSS-REFERENCE TO RELATED APPLICATION
This application claims priority of Taiwan Patent Application No. 105119842, filed on Jun. 24, 2016, the content of which is incorporated herein in its entirety by reference.
BACKGROUND OF THE INVENTION
1. Field of the Invention
The present invention relates to
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