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Hes-6, an inhibitor of Hes-1, is regulated by 17beta-estradiol and promotes breast cancer cell proliferation.

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BACKGROUND Hes-6 is a member of the basic helix-loop-helix (bHLH) family of transcription factors, and its overexpression has been reported in metastatic cancers of different origins. Hes-6 has been described as an inhibitor of Hes-1 during neuronal development, although its function in cancer is

[Antitumor effect of polysaccharide lentinan on C3H/He mice bearing MH134 ascites hepatoma].

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1. Lentinan inhibited the proliferation of MH 134 ascites hepatoma transplanted subcutaneously into C3H/He mice, but its most favorite effect appeared when 1mg-2mg/Kg of lentinan was administered for 10 consecutive days from the eighth day after tumor transplantation, yielding a tumor

Antitumor effect of polysaccharide lentinan on MH-134 ascites hepatoma in C3H/He mice.

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Lentinan inhibited the proliferation of MH-134 ascites hepatoma transplanted subcutaneously. The best result occurred when 1 mg-2 mg/kg of lentinan was administered for 10 consecutive days from the eighth day after tumor transplantation. Tumor proliferation was 33% inhibited as measured by the

[Type A adenocarcinoma grafted into C3H/he-M mice subjected to treatment with various antineoplastic agents. I. Biological study].

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The biological modifications in C3H/he-M mice treated with vincristine, prospidium chloride and adriamycin are studied. A significative reduction of the tumor volume was observed with prospidium chloride and adriamycin treatment. The index of tumour growth inhibition (I0) is very high and

Anti-tumor necrosis factor-alpha treatment activates Borrelia burgdorferi spirochetes 4 weeks after ceftriaxone treatment in C3H/He mice.

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BACKGROUND The effect of anti-tumor necrosis factor (TNF)-alpha treatment in Borrelia burgdorferi-infected and ceftriaxone-treated C3H/He mice was evaluated. METHODS Mice were infected with B. garinii A218 or B. burgdorferi sensu stricto N40. At 2 weeks of infection, one group was treated

[Type A adenocarcinoma grafted into C3H/he mice subjected to treatment with various antineoplastic agents. II. Histopathological and ultrastructural study].

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We studied the histopathological and ultrastructural modifications which the adenocarcinoma type A grafted to C3 H/he-M mice manifested on being treated with vincristine, prospidium chloride and adriamycin. With M/O the tumors treated with prospidium chloride and adriamycin showed a greater

Antitumor effect of bacterial lipopolysaccharide (LPS) alone and in combination with lentinan on MH-134 tumors in C3H/He mice.

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Using C3H/He mice, the antitumor effect of lipopolysaccharide (LPS) alone and in combination with Lentinan extracted from Lentinus edodes was studied. The influence of LPS on cellular immunity and the antitumor effect of the tumor necrosis factor (TNF) were also examined. LPS, which was administered

[Inducing differentiation effect on cells of serum from mice treated with Yang He decoction].

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OBJECTIVE To observe inducing differention effect on cells of serum from mice treated with Yang He decoction (SMY). METHODS The viability of B16 cells was tested by lactate dehydrogenase (LDH) release assay and sulforhordamine B (SRB) assay. The differentiation of 3T3-L1 preadipocyte, HL-60, K562

[Antitumor effect of bacterial lipopolysaccharide (LPS) and a combination use of LPS and lentinan on C3H/He mice bearing MH-134 tumor].

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Using C3H/He mice a series of experiments was carried to study the antitumor effect of lipopolysaccharide (LPS) in combined use with Lentinan extracted from Cortinellus shiitake and its influence on cellular immunity as well as antitumor effect of tumor necrosis factor (TNF) prepared from LPS, and

Baicalein suppresses the proliferation of human cervical cancer cells via Notch 1/Hes signaling pathway.

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Baicalein is an active compound extracted from the roots of Scutellaria baicalensis georgi, which is widely and traditionally used in the anticancer therapy. Notch signaling pathway is usually abnormally activated in kinds of human cancers. The aim of the present study is to

Synergistic Effect of H2O2 and NO2 in Cell Death Induced by Cold Atmospheric He Plasma.

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Cold atmospheric pressure plasmas (CAPPs) have emerged over the last decade as a new promising therapy to fight cancer. CAPPs' antitumor activity is primarily due to the delivery of reactive oxygen and nitrogen species (RONS), but the precise determination of the constituents linked to this

Intratumor immunochemotherapy with 5-fluorouracil emulsion and BCG in C3H/HE mice transplanted with MH134.

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Responses to intratumor immunochemotherapy by intralesional injections of BCG and 5-fluorouracil (5-FU) emulsion, prior to resection of a transplanted primary tumor, were investigated using a host-tumor system consisting of C3H/He mice and MH134. A significant prolongation of survival and

[Restoration of depressed immune responses by PSK in C3H/He mice bearing the syngeneic X5563 tumor].

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PSK is a protein-bound polysaccharide prepared from cultured mycelium of Coriolus versicolor. The effects of PSK on immunologic responsiveness were investigated in C3H/He mice bearing syngeneic X5563 tumor. The results were as follows. elayed foot pad reaction and antibody-forming capacity to sheep

Combination therapy of radiation and immunomodulators in the treatment of MM46 tumor transplanted in C3H/He mice.

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Female C3H/He mice aged 10 weeks with transplanted MM46 tumor were used in an investigation of the timing of administration of immunomodulators, such as PSK (a protein-bound polysaccharide prepared from Coriolus versicolor), OK-432 (streptococcal preparation), bestatin (inhibitor of aminopeptidase

Inhibition of C3H/He mouse mammary tumor growth by combined treatment with cyclophosphamide and polyadenylic-polyuridylic acid.

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The antitumor effect of an immunomodulator, polyadenylic-polyuridylic acid, in combination with cyclophosphamide (CY) was studied in C3H/He mice bearing established mammary tumors. On Day 14 after tumor graft, mice received either CY (90 mg/kg) alone every 2 weeks for a total of four inoculations or

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