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In vitro deterioration of rhein anthraquinone in cecal content of rats.

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The influence of the intestinal microbial reduction of rhein anthraquinone on the formation of deterioration products was studied. Therefore [14C]rhein and [14C]rhein anthrone were mixed with sterilized or non-sterilized cecal mass of rats and incubated for 20 hours at 37 degrees C. Extractions with

Novel derivatives of 9,10-anthraquinone are selective algicides against the musty-odor cyanobacterium Oscillatoria perornata.

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Musty "off-flavor" in pond-cultured channel catfish (Ictalurus punctatus) costs the catfish production industry in the United States at least 30 million US dollars annually. The cyanobacterium Oscillatoria perornata (Skuja) is credited with being the major cause of musty off-flavor in farm-raised

Ultrastructure of mouse intestinal mucosa and changes observed after long term anthraquinone administration.

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In an attempt to study the relative toxicity of anthraquinonic laxatives on intestinal mucosa, we compared in mice the effects of fruit pulp containing sennosides A and B with those of a free anthraquinone, 1-8 dihydroxyanthraquinone. Observations have been made with transmission electron microscopy

Anthraquinone from Edible Fungi Pleurotus ostreatus Protects Human SH-SY5Y Neuroblastoma Cells Against 6-Hydroxydopamine-Induced Cell Death-Preclinical Validation of Gene Knockout Possibilities of PARK7, PINK1, and SNCA1 Using CRISPR SpCas9.

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Parkinson's disease (PD) results from the degeneration of the nervous tissue brought about by ecological and hereditary components which affects nerve cells in the brain. It is the world's second most normal neurodegenerative issue, which can essentially weaken the personal satisfaction, make

Toxicity of an anthraquinone violet dye mixture following inhalation exposure, intratracheal instillation, or gavage.

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Anthraquinone dyes are utilized by the military in colored-smoke grenades. During production, workers in munitions plants may be exposed to fugitive emissions of these dyes or mixtures thereof. The effects of a prototype violet dye mixture (VDM) consisting of Disperse Red 11 (DR11),

Acute renal failure associated with prolonged intake of slimming pills containing anthraquinones.

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Chinese herbal medicine preparations are widely available and often regarded by the public as natural and safe remedies for a variety of medical conditions. Nephropathy caused by Chinese herbs has previously been reported, usually involving the use of aristolochic acids. We report a 23-year-old

[Protection and bidirectional effect of rhubarb anthraquinone and tannins for rats' liver].

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OBJECTIVE To compare the bidirectional effect of rhubarb total anthraquinone (TA) and total tannins (TT) on rats' liver. METHODS One hundred rats were randomly divided into 10 groups, i.e., the blank group, the model group, the blank + high dose TA group, the blank +low dose TA group, the blank +

Oral colon-specific drug delivery system reduces the nephrotoxicity of rhubarb anthraquinones when they produce purgative efficacy.

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Rhubarb is commonly used to treat constipation in China and anthraquinones (AQs) are the active components present in rhubarb. However, an increasing number of studies have reported that AQs induce nephrotoxicity. In the present study, rhubarb total free anthraquinones (RTFA) oral colon-specific

Rhein: a potential biological therapeutic drug for intervertebral disc degeneration.

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Intervertebral disc degeneration (IDD) is regarded as an important cause of low back pain, which continues to be a common disability. IDD is thought to involve sequential changes of intervertebral disc that lead to the reduction of disc cells and the extracellular matrix. In addition, inflammation

Anthraquinone-2,6-disulfonic acid as a disease-modifying osteoarthritis drug: an in vitro and in vivo study.

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Pharmacologic treatment of osteoarthritis has been confined mostly to analgesic or nonsteroidal antiinflammatory drugs that only modify the symptoms. We asked whether anthraquinone-2,6-disulfonic acid might act as a disease-modifying osteoarthritis drug. We evaluated the in vitro inhibitory effect

[Isolation and charcterizaiton of a polyketide synthase gene cluster from Usnea longissima].

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OBJECTIVE To isolate polyketide synthase (PKS) gene from medicinal Usnea longissima lichen forming fungi, and identify the function of obtained PKS. METHODS We used Usnea. longissima lichen forming fungi to isolate PKS gene by nested PCR using degenerate primers and screening a Fosimid genomic

Morphologic effects of mitoxantrone and a related anthracenedione on lymphoid tissues.

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A single non-toxic dose of mitoxantrone or a related anthraquinone derivative caused extensive destruction of splenic marginal zone cells in rats and mice. This was followed by phagocytosis of cell debris and long-lasting atrophy. Germinal centers of splenic follicles were also affected. Small doses

Spectroscopic and calorimetric studies on the mechanism of methylenecyclopropane rearrangements triggered by photoinduced electron transfer.

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2-(dideuteriomethylene)-1,1-bis(4-methoxyphenyl)cyclopropane (d(2)-1) undergoes degenerate rearrangement in both singlet- and triplet-sensitized electron-transfer photoreactions. Nanosecond time-resolved absorption spectroscopy on laser flash photolysis of the unlabeled 1 with

Promoting Solution Discharge of Li-O2 Batteries with Immobilized Redox Mediators.

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For years, the aprotic Li-O2 battery suffered from a severe capacity-current trade-off that would be unacceptable for a beyond Li-ion battery. Recent fundamental study of Li-O2 electrochemistry revealed that this dilemma is caused by the growth of Li2O2 on the cathode surface and can be solved by

A transcribed polyketide synthase gene from Xanthoria elegans.

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We characterize the transcript of a polyketide synthase gene (PKS) from the cultured mycobiont of Xanthoria elegans (XePKS1) using SMART-rapid amplification of cDNA ends (RACE) cDNA synthesis. Sequence analysis of the cloned cDNA reveals an open reading frame of 2144 amino acid residues. It contains

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