A placebo solution will be applied on the quadriceps of one of the lower limbs immediately after the exercise protocol and daily for 7 consecutive days.

A natural aloe vera solution (peel and leaf) will be applied on the quadriceps of one of the lower limbs immediately after the exercise protocol and daily for 7 consecutive days.

An aloe vera soup solution will be applied on the quadriceps of one of the lower limbs immediately after the exercise protocol and daily for 7 consecutive days.

Skeletal Muscle Damage

Exercise-induced Aseptic Inflammation

Performance

A placebo solution that will not include aloe vera will be applied on the quadriceps of one of the lower limbs.

Placebo

Natural aloe vera solution including peel and leaf from aloe will be applied on the the quadriceps of one of the lower limbs.

Natural Aloe Vera

Aloe vera solution including aloe vera soup will be applied on the the quadriceps of one of the lower limbs.

Aloe vera soup

SmArT LABORATORY, SCHOOL OF PHYSICAL EDUCATION & SPORTS SCIENCES, UNIVERSITY OF THESSALY

Aloe Vera Ointment Application and Skeletal Muscle Recovery

Effect of Aloe Vera Ointment Application on Muscle Damage and Performance Recovery Kinetics Following an Intense Eccentric Exercise Protocol: A Pilot Study.

Creatine kinase activity will be measured in plasma by utilizing a Clinical Chemistry Analyzer and commercially available kits.

Maximal knee extensor concentric, eccentric and isometric peak torque will be measured on an isokinetic dynamometer.

Muscle soreness will be assessed during palpation of the muscle belly and the distal region of relaxed quadriceps muscle following three repetitions of a full squat.

Ioannis G. Fatouros

Professor

University of Thessaly

All subjects will be given placebo identically matched with regard to shape, color and taste. They will be given one tablet/day for 2 weeks and then two tablets/day for the duration of sudy.

All subjects will be given diacerein with a starting dose of 50 mg in one tablet once daily for 2 weeks. After 2 weeks, they will be given diacerein 50 mg in one tablet twice daily for the duration of sudy.

Diabetes Mellitus, Type 2

Non-alcoholic Fatty Liver Disease

Diacerein

Sugar pill manufactured to mimic Diacerein

Program of Arterial Hypertension, University Hospital Clementino Fraga Filho

Efficacy Study of Diacerein on Glycemic Control and Liver Fat in Type 2 Diabetes Subjects

Reduction of mean glycated hemoglobin (≥ 1%) and reduction of liver fat fraction as measured by transient elastography (≥ 20%)

Reduction of albumin excretion rate on 24-hour urine collection

Elevation of high molecular weight adiponectin and reduction of the apoptotic by-product cytokeratin (CK)-18

anthraquinone/inflamação

Aloe Vera Ointment Application and Skeletal Muscle Recovery

Efficacy Study of Diacerein on Glycemic Control and Liver Fat in Type 2 Diabetes Subjects

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