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Phytoremediation of carbamazepine and its metabolite 10,11-epoxycarbamazepine by C3 and C4 plants.
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The anticonvulsant drug carbamazepine is considered as an indicator of sewage water pollution: however, its uptake by plants and effect on metabolism have not been sufficiently documented, let alone its metabolite (10,11-epoxycarbamazepine). In a model system of sterile, hydroponically cultivated
Effects of toluene on seizures induced by convulsants acting at distinct ligand-gated ion channels.
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Toluene is one of the most widely used solvents. Electrophysiological studies indicated that this solvent directly affects various ligand gated ion channels including NMDA, GABA(A), nicotinic and glycine receptors. The effect of toluene on seizures induced by chemoconvulsants acting on these
Effects of hexachlorocyclohexane isomers on the acquisition of kindled seizures.
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The effects of three isomers (alpha, beta, gamma) of hexachlorocyclohexane on the acquisition and expression of kindled amygdaloid seizures were compared. Treatment with corn oil (vehicle) was compared with daily 5 mg/kg doses of the isomers for 15 days during kindling procedures. The results
Process and formulation variables of pregabalin microspheres prepared by w/o/o double emulsion solvent diffusion method and their clinical application by animal modeling studies.
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Pregabalin is an anticonvulsant drug used for neuropathic pain and as an adjunct therapy for partial seizures with or without secondary generalization in adults. In conventional therapy recommended dose for pregabalin is 75 mg twice daily or 50 mg three times a day, with maximum dosage of 600 mg/d.
Effects of two isomers of hexachlorocyclohexane (HCH) on cortical beta-adrenoceptors in rat brain.
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Two isomers of hexachlorocyclohexane (HCH) have profound effects on the acquisition of kindled seizures. The gamma-isomer (lindane, gamma-HCH) increases the rate of acquisition in a dose-related manner whereas the beta-isomer (beta-HCH) has the opposite effect, retarding the rate in a dose-related
Developmental toxicity and structure-activity relationships of aliphatic acids, including dose-response assessment of valproic acid in mice and rats.
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The anticonvulsant valproic acid (VPA), or 2-propylpentanoic acid, is a short-chain aliphatic acid that is teratogenic in humans and rodents. VPA and 14 related chemicals were screened for developmental toxicity using the Chernoff/Kavlock assay. Test agents, in corn oil, were administered by gavage
Seizure susceptibility alteration following reversible cholestasis in mice: Modulation by opioids and nitric oxide.
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There is an increasing body of evidence that the central nervous system is affected by cholestatic liver disorders. Cholestasis has been shown to result in a decreased seizure propensity which is believed to be mediated by an increased opioidergic tone and nitric oxide (NO) signaling pathway. In
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