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arnebia/prostaglandin
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3 resultados
Biologically active constituents of Arnebia euchroma: structure of arnebinol, an ansa-type monoterpenylbenzenoid with inhibitory activity on prostaglandin biosynthesis.
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Three phenolic compounds were isolated from the roots of Arnebia euchroma as inhibitors of in vitro prostaglandin biosynthesis. Two known compounds were identified as shikonofurans and des-O-methyllasiodiplodin. The other new compound was named arnebinol and its structure was elucidated as a novel
Development and use of a gene promoter-based screen to identify novel inhibitors of cyclooxygenase-2 transcription.
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Cyclooxygenase-2 (COX-2) is a recognized target for cancer prevention and possibly treatment. To identify novel inhibitors of COX-2, we developed a high throughput reporter gene assay that utilizes a region of the human COX-2 promoter to drive luciferase expression. A total of 968 extracts from 266
Inhibition on platelet activation by shikonin derivatives isolated from Arnebia euchroma.
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Acetylshikonin, teracrylshikonin, beta,beta-dimethylacrylshikonin and shikonin, isolated from Arnebia euchroma, inhibited collagen (10 micrograms/ml)-induced aggregation of washed rabbit platelets in a concentration-dependent manner with IC50 values of 2.1 +/- 0.2, 2.8 +/- 0.3, 4.2 +/- 0.5 and 10.7
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