asphyxia neonatorum/crise epiléptica

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[Preventive treatment of convulsions in perinatal asphyxia].

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A double blind randomized study has been performed in 17 newborn infants bearing a diagnosis of perinatal asphyxia and treated with phenobarbital (FB) or phenytoin (DPH) to prevent the onset of seizures. The initial dose for both drugs was 12 m/kg IM the first day, followed by 6 mg/kg/day through

Predictors of outcome in term infants with neonatal seizures subsequent to intrapartum asphyxia.

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The objective of this study was to define potential clinical prognostic factors for term infants with neonatal seizures subsequent to intrapartum asphyxia. The authors completed a retrospective analysis of 62 term infants with clinical neonatal seizures subsequent to intrapartum asphyxia. Logistic

Seizure-associated brain injury in term newborns with perinatal asphyxia.

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BACKGROUND There is controversy over whether seizures, the most common manifestation of neonatal brain injury, may themselves damage the developing brain. OBJECTIVE To determine if neonatal seizures are independently associated with brain injury in newborns with perinatal asphyxia. METHODS Ninety

OXYTOCIN REDUCES SEIZURE BURDEN AND HIPPOCAMPAL INJURY IN A RAT MODEL OF PERINATAL ASPHYXIA.

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Foetal asphyxia, a frequent birth complication, detrimentally impacts the immature brain, resulting in neuronal damage, uncontrolled seizure activity and long-term neurological deficits. Oxytocin, a neurohormone mediating important materno-foetal interactions and parturition, has been

Brain alkalosis causes birth asphyxia seizures, suggesting therapeutic strategy.

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OBJECTIVE The mechanisms whereby birth asphyxia leads to generation of seizures remain unidentified. To study the possible role of brain pH changes, we used a rodent model that mimics the alterations in systemic CO(2) and O(2) levels during and after intrapartum birth asphyxia. METHODS Neonatal rat

Acid extrusion via blood-brain barrier causes brain alkalosis and seizures after neonatal asphyxia.

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Birth asphyxia is often associated with a high seizure burden that is predictive of poor neurodevelopmental outcome. The mechanisms underlying birth asphyxia seizures are unknown. Using an animal model of birth asphyxia based on 6-day-old rat pups, we have recently shown that the seizure burden is

Seizure-associated brain injury in term newborns with perinatal asphyxia.

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Obstetrics and Gynæcology: Sugar in Uterine Inertia-The Minute Anatomy of the Fallopian Tubes-The Incision in Abdominal Surgery-The Treatment of Asphyxia Neonatorum-Restoration of Life by Rhythmical Tractions on the Tongue-Care of the Navel-On Puerperal Albuminuria and Convulsions, &c.

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Convulsions following birth asphyxia/birth trauma--are long-term anticonvulsants necessary?

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Changes in risk factors for hypoxic-ischaemic seizures in term infants.

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Term infants with seizures and evidence of perinatal asphyxia were prospectively identified in 1 city and 2 time periods: 1978-1981 and 1991. Infants with multiple congenital abnormalities, hypocalcaemia or infection were excluded. Although there was little change in the overall incidence of

Term neonatal asphyxial seizures and peripartum deaths: lack of correlation with a rising cesarean delivery rate.

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OBJECTIVE The purpose of this analysis was to study the relationship between an increasing cesarean delivery rate and term neonatal seizures and peripartum deaths. METHODS This was a retrospective analysis of annually collated institutional data on cesarean delivery and perinatal outcome. RESULTS Of

Pattern, etiological factors and determinants of mortality among sick newborns with seizures in Ilesa, Nigeria.

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BACKGROUND Neonatal seizures contribute significantly to newborn morbidity and mortality particularly in developing countries including Nigeria. Unfortunately the countries with high incidence of neonatal seizures often lack the facilities to adequately diagnose, monitor and prognosticate the

Heart rate changes are insensitive for detecting postasphyxial seizures in neonates.

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We studied heart rate (HR) changes during 169 seizures (mean 12 per patient, range 8 to 18) in 14 neonates with severe birth asphyxia. HR changes were found in 21 seizures (12.4%) in eight patients (HR increases in four, decreases in one, and both patterns in three patients), suggesting the

Neonatal seizures. I. Correlation of prenatal and perinatal events with outcomes.

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A review of 277 newborns with neonatal seizures enrolled in the Collaborative Perinatal Project revealed a mortality of 34.8%. Of the 181 survivors, most followed up to age 7 years, 70% were normal. Thus, despite the fact that seizures are a major indicator of perinatal asphyxia and a predictor of

Neonatal seizures and a 2-year neurological outcome.

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A study of 57 infants with neonatal seizures admitted to the Special Care Baby Unit of the Jos University Teaching Hospital over a 3-year period showed perinatal asphyxia and hypoglycaemia as the principal aetiologic factors in 47 and 19 per cent of the cases, respectively. Seizures were commoner in

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