Atherosclerosis / protease

Cyanamides useful as reversible inhibitors of cysteine proteases

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FIELD OF THE INVENTION This invention relates to cyanamide compounds useful as reversible inhibitors of the cysteine proteases cathepsins S, K, F, L and B. Certain embodiments described are preferable for inhibition of cathepsin K. The compounds are therefore useful in the treatment of cysteine

Method of treating diseases mediated by cyclic nucleotide pathways with purified stem bromelain protease

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BACKGROUND OF THE INVENTION The present invention relates to the use of one of the components of the enzyme mixture bromelain in the treatment of various conditions which are dependent on cyclic nucleotide and other intracellular and/or extracellular pathways. Work has already been carried out on

Protease-activated receptor 3 and uses thereof

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FIELD OF THE INVENTION This invention relates to nucleic acids, their encoded protease-activated receptor 3 proteins, and screening assays for agonists and antagonists of the protease activated receptor 3 proteins. BACKGROUND OF THE INVENTION Thrombin, a coagulation protease generated at sites of

DNA encoding a protease-activated receptor 3

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FIELD OF THE INVENTION This invention relates to nucleic acids, their encoded protease-activated receptor 3 proteins, and screening assays for agonists and antagonists of the protease activated receptor 3 proteins. BACKGROUND OF THE INVENTION Thrombin, a coagulation protease generated at sites of

Catalytic monoclonal antibodies with protease activity for selective lysis of protein component of plaques aggregates pathological conditions

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The present invention relates to catalytic monoclonal antibodies, in particular with protease activity, for the selective lysis of the protein component of plaques and aggregates related to pathological conditions. Alzheimer's Disease Alzheimer's disease (AD) is a degenerative disease which affects

Regulation of human transmembrane serine protease

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TECHNICAL FIELD OF THE INVENTION The invention relates to the area of regulation human transmembrane serine protease activity to provide therapeutic effects. BACKGROUND OF THE INVENTION Metastasizing cancer cells invade the extracellular matrix using plasma membrane protrusions that contact and

Regulation of human transmembrane serine protease

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TECHNICAL FIELD OF THE INVENTION The invention relates to the area of regulation human transmembrane serine protease activity to provide therapeutic effects. BACKGROUND OF THE INVENTION Metastasizing cancer cells invade the extracellular matrix using plasma membrane protrusions that contact and

Regulation of human transmembrane serine protease

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TECHNICAL FIELD OF THE INVENTION The invention relates to the area of regulation human transmembrane serine protease activity to provide therapeutic effects. BACKGROUND OF THE INVENTION Metastasizing cancer cells invade the extracellular matrix using plasma membrane protrusions that contact and

Nitriles useful as reversible inhibitors of cysteine proteases

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FIELD OF THE INVENTION This invention relates to peptidyl carbamates and related compounds. The compounds are reversible inhibitors of the cysteine proteases cathepsins S, K, F, L and B and certain embodiments described are preferable for inhibition of cathepsin K. The compounds are therefore useful

Farnesyltransferase inhibitors for treatment of laminopathies, cellular aging and atherosclerosis

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FIELD This disclosure relates to treatment of laminopathies, cellular aging and aging-related conditions, and more particularly to the use of farnesyltransferase inhibitors (FTIs) and other compounds and compositions to treat such conditions. It also relates to methods of identifying agents useful

Farnesyltransferase inhibitors for treatment of laminopathies, cellular aging and atherosclerosis

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FIELD This disclosure relates to treatment of laminopathies, cellular aging and aging-related conditions, and more particularly to the use of farnesyltransferase inhibitors (FTIs) and other compounds and compositions to treat such conditions. It also relates to methods of identifying agents useful

Farnesyltransferase inhibitors for treatment of laminopathies, cellular aging and atherosclerosis

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FIELD This disclosure relates to treatment of laminopathies, cellular aging and aging-related conditions, and more particularly to the use of farnesyltransferase inhibitors (FTIs) and other compounds and compositions to treat such conditions. It also relates to methods of identifying agents useful

Farnesyltransferase inhibitors for treatment of laminopathies, cellular aging and atherosclerosis

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FIELD This disclosure relates to treatment of laminopathies, cellular aging and aging-related conditions, and more particularly to the use of farnesyltransferase inhibitors (FTIs) and other compounds and compositions to treat such conditions. It also relates to methods of identifying agents useful

Serine protease inhibitors-N-substituted derivatives

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The present invention relates to certain substituted oxadiazole, thiadiazole and triazole peptoids which are useful as inhibitors of serine proteases. BACKGROUND OF THE INVENTION The serine proteases are a class of enzymes which includes elastase, chymotrypsin, cathepsin G, trypsin and thrombin.

Regulation of human prostasin-like serine protease

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This application is a National Stage application of co-pending PCT application PCT/EP01/07116 filed Jun. 22, 2001, which was published in English under PCT Article 21(2) on Dec. 27, 2001, which claims the benefit of U.S. provisional application Ser. No. 60/213,474 filed Jun. 23, 2000 and Ser. No.

atherosclerosis/protease

Cyanamides useful as reversible inhibitors of cysteine proteases

Method of treating diseases mediated by cyclic nucleotide pathways with purified stem bromelain protease

Protease-activated receptor 3 and uses thereof

DNA encoding a protease-activated receptor 3

Catalytic monoclonal antibodies with protease activity for selective lysis of protein component of plaques aggregates pathological conditions

Regulation of human transmembrane serine protease

Regulation of human transmembrane serine protease

Regulation of human transmembrane serine protease

Nitriles useful as reversible inhibitors of cysteine proteases

Farnesyltransferase inhibitors for treatment of laminopathies, cellular aging and atherosclerosis

Farnesyltransferase inhibitors for treatment of laminopathies, cellular aging and atherosclerosis

Farnesyltransferase inhibitors for treatment of laminopathies, cellular aging and atherosclerosis

Farnesyltransferase inhibitors for treatment of laminopathies, cellular aging and atherosclerosis

Serine protease inhibitors-N-substituted derivatives

Regulation of human prostasin-like serine protease

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