The lower dose CBD group will start with CBD capsules 5 mg BID, then increase the dose every 4 days until on the target dose of 50 mg BID.

The higher dose CBD group will start with CBD capsules 5 mg BID and will increase every 4 days until on a target dose of 100 mg BID.

Chronic Migraine

CBD oil - purified to <1% THC in soft-gel capsules

CBD 50 mg BID

CBD 100 mg BID

Placebo

Cannabis for the Prophylactic Treatment of Migraine

Cannabis for the Prophylactic Treatment of Migraine: a Randomized Double-Blind Placebo-Controlled Clinical Trial

The MIDAS test assesses the impact of migraines on daily life. The score ranges between 0 and 21+ with a lower score indicating little or no disability and a higher score indicating severe disability.

The HIT-6 test score ranges between 36-78 with a higher score being associated with greater impact of headache on an individual's life.

The GAD-7 patient questionnaire is used as a screening tool for generalized anxiety disorder with scores ranging between 0-21. A higher score is associated with a probable diagnosis of severe anxiety.

The PHQ-9 questionnaire is a self-administered screening tool for depression. The questionnaire score can range between 0-27 with higher scores indicating severe depression.

The MSQ assesses the impact (restrictive, preventative and emotional) of migraine on an individual's quality of life.

The PSQI is a tool used to measure the quality of an individual's sleep. The PSQI is self-administered with a higher score indicating overall poor sleep.

Farnaz Amoozegar

MD, Assistant Professor

University of Calgary

Prometrium 200mg. Take one pill in the evening on day 1 with water. Take one pill twice a day on days 2-4. Take one pill on morning day 5.

Placebo. ake one pill in the evening on day 1 with water. Take one pill twice a day on days 2-4. Take one pill on morning day 5.

Prometrium 200mg. Take one pill in the evening on day 1 with water. Take one pill twice a day on days 2-4. Take one pill on morning day 5.
Progesterone: Progesterone capsule

Progesterone

Placebo. ake one pill in the evening on day 1 with water. Take one pill twice a day on days 2-4. Take one pill on morning day 5.
Placebo: Placebo capsule. Manufactured to mimic progesterone 200mg capsule.

Total

Sex: Female, Male

Race (NIH/OMB)

Region of Enrollment

Participants took progesterone or placebo for 5 days. Salivary progesterone was measured each day. Change score was calculating by subtracting Day 1 progesterone levels from Day 5 progesterone levels.

Change in Salivary Progesterone Level

Participants took progesterone or placebo for 5 days. The Cannabis Withdrawal Scale was administered each day. The 19-item scale is used to measure cannabis withdrawal symptoms and negative impact on daily life. The item scores range from 0 - not at all to 10- Extremely. Scores on all items are summed to attain the scale score, so individuals can score between 0-190. Higher scores indicates more severe withdrawal symptoms and greater negative impact. Change score was calculating by subtracting Day 1 CWS scores from Day 5 CWS scores. A positive change score reflects an increase in withdrawal symptoms, while a negative change score reflects a decrease in withdrawal symptoms.

Change in Cannabis Withdrawal Scale Score.

Overall Study

Dr. Sherman

Cannabis Use Disorder

Cannabis Withdrawal

Placebo capsule. Manufactured to mimic progesterone 200mg capsule.

Medical University of South Carolina

Progesterone for Cannabis Withdrawal

Progesterone for the Treatment of Cannabis Withdrawal

National Institute on Drug Abuse (NIDA)

National Institutes of Health (NIH)

Cannabis Use

Repetitive Transcranial Magnetic Stimulation

Maryland Psychiatric Research Center (MPRC) 55 Wade Avenue

Pilot Study Repetitive Transcranial Magnetic Stimulation (rTMS) in Cannabis Craving

University of Maryland, College Park

Quetiapine + Placebo
quetiapine + placebo: placebo (titrated to 150-300 mg/day) in combination with quetiapine (titrated to 400-800 mg/day).

Quitiapine + Placebo

Quetiapine + Topiramate
Quetiapine + Topiramate: topiramate (titrated to 150-300 mg/day) in combination with Quetiapine (titrated to 400-800 mg/day).

Quetiapine + Topiramate

Change in timeline follow-back self-reported of joint equivalents per week from baseline to 16 weeks.

Quetiapine and Placebo
Quetiapine and placebo: placebo (titrated to 150-300 mg/day) in combination with quetiapine (titrated to 400-800 mg/day).

Quitiapine and Placebo

Quetiapine and Topiramate
Quetiapine and Topiramate: topiramate (titrated to 150-300 mg/day) in combination with Quetiapine (titrated to 400-800 mg/day).

Quetiapine and Topiramate

Change in Joints Per Week

Change in percent days of cannabis use per week from baseline to week 16.

Change in Percent Days of Cannabis Use Per Week

Melissa P. DelBello, MD

Bipolar Disorder

Cannabis-Related Disorder

placebo (titrated to 150-300 mg/day) in combination with quetiapine (titrated to 400-800 mg/day).

Quetiapine and placebo

topiramate (titrated to 150-300 mg/day) in combination with Quetiapine (titrated to 400-800 mg/day).

cannabis/cefaleia

Cannabis for the Prophylactic Treatment of Migraine

Progesterone for Cannabis Withdrawal

Pilot Study Repetitive Transcranial Magnetic Stimulation (rTMS) in Cannabis Craving

Efficacy Study of Quetiapine Plus Topiramate for Reducing Cannabis Consumption and Bipolar Mania

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