chronic periodontitis/protease

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[Analysis of salivary protease spectrum in chronic periodontitis].

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OBJECTIVE This study aimed to investigate the difference in salivary protease expression in patients with chronic periodontitis and normal individuals. METHODS The stimulating saliva in patients with chronic periodontitis and normal individuals were collected. Protein chip technology was adapted to

Long-term monitoring of adult periodontitis patients in supportive periodontal therapy: correlation of gingival crevicular fluid proteases with probing attachment loss.

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The aim of this retrospective study was to determine if a chairside assay for neutral protease activity in gingival crevicular fluid (GCF) could provide an early indication of site-specific disease activity, as defined by probing attachment loss. Clinical measures and assay data were collected at

Analysis of in situ protease activity in chronic adult periodontitis patients: expression of activated MMP-2 and a 40 kDa serine protease.

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BACKGROUND Periodontitis is characterized by extensive destruction of the gingival tissues and associated supporting structures of the teeth. Although the pathogenesis of the various forms of this disease is not completely understood, host-derived proteases are believed to have an important role. In

The short-term effectiveness of non-surgical treatment in reducing protease activity in gingival crevicular fluid from chronic periodontitis patients.

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OBJECTIVE The aim of this study was to evaluate the short-term effect of non-surgical periodontal treatment on protease activity in gingival crevicular fluid (GCF) of patients with chronic periodontitis. METHODS After clinical examination, in which pocket probing depth, probing attachment level,

Expression of protease-activated receptors 1 and 2 in individuals with healthy gingiva and chronic periodontitis.

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UNASSIGNED Protease-activated receptors (PAR-1 and PAR-2) are found to be immensely exhibited in the periodontal tissues. These receptors are involved in the inflammatory and repair processes. Activation of PARs is mainly by the bacterial and endogenous enzymes. The aim of the study was to determine

Toward the definition of a peptidome signature and protease profile in chronic periodontitis.

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OBJECTIVE Chronic periodontitis (CP) is a complex immuno-inflammatory disease that results from preestablished gingivitis. We investigated potential differences in salivary peptidome in health and CP. METHODS Saliva was collected from nine CP patients and ten healthy subjects, from which five CP and

Expression of protease activated receptor-1 in chronic periodontitis.

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BACKGROUND Protease activated receptor-1 (PAR1) activation by thrombin may play a role in repair and homeostasis of periodontal tissues. The main objective of this study is to investigate PAR1 expression in patients with periodontitis, before and after non-surgical periodontal treatment, and to

Human β-defensin 2 and protease activated receptor-2 expression in patients with chronic periodontitis.

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OBJECTIVE Some previous studies have shown that gingipains, trypsin-like proteases produced by Porphyromonas gingivalis, up-regulate human β defensin-2 (HBD-2) mRNA expression through protease-activated receptor-2 (PAR(2)) in gingival epithelial cells. This study aimed at investigating salivary

Porphyromonas gingivalis is associated with protease-activated receptor-2 upregulation in chronic periodontitis.

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BACKGROUND We previously reported a higher expression of protease-activated receptor-2 (PAR(2)) together with higher interleukin (IL)-1α, IL-6, IL-8, and tumor necrosis factor-α levels, total proteolytic activity, Porphyromonas gingivalis (Pg) prevalence, and neutrophil-protease 3 messenger RNA

Analysis of cultivable Porphyromonas gingivalis with trypsin-like protease enzyme activity and serum antibodies in chronic adult periodontitis.

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OBJECTIVE Trypsin-like protease (TLPase) enzyme produced by Porphyromonas gingivalis has been implicated as a virulence factor in the pathogenesis of periodontal disease. The aims of this study were to investigate the relationship between cultivable P. gingivalis, TLPase enzyme activity (BANA

[The results of the clinical use of the immobilized-protease enzyme profezim in treating exacerbated chronic periodontitis].

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The authors characterize the action of profezyme, an immobilized proteinase enzyme, used in the treatment of patients with exacerbations of chronic periodontitis. Time course of symptomatology was followed up in 65 patients in various periods of periodontitis therapy. Prolonged enzymic therapy

Secretory leukocyte protease inhibitor and its potential interactions with elastase and cathepsin B in gingival crevicular fluid and saliva from patients with chronic periodontitis.

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OBJECTIVE Elastase is carried into the oral cavity by gingival crevicular fluid (GCF) from periodontal lesions. Our study investigated the regulation of elastase activity by secretory leukocyte protease inhibitor (SLPI) and the possible action of another GCF protease on this protective salivary

The Short-Term Effectiveness of Non-Surgical Treatment in Reducing Levels of Interleukin-1β and Proteases in Gingival Crevicular Fluid From Patients With Type 2 Diabetes Mellitus and Chronic Periodontitis.

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BACKGROUND This study aimed to compare the effectiveness of non-surgical periodontal treatment in improving periodontal status and reducing gingival crevicular fluid (GCF) levels of interleukin (IL)-1β and IL-18, elastase activity, and matrix metalloproteinase (MMP)--8 and --9 in periodontitis

The short-term effectiveness of non-surgical treatment in reducing levels of interleukin-1beta and proteases in gingival crevicular fluid from patients with type 2 diabetes mellitus and chronic periodontitis.

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BACKGROUND This study aimed to compare the effectiveness of non-surgical periodontal treatment in improving periodontal status and reducing gingival crevicular fluid (GCF) levels of interleukin (IL)-1beta and IL-18, elastase activity, and matrix metalloproteinase (MMP)--8 and --9 in periodontitis

Periodontal pathogens affect the level of protease inhibitors in gingival crevicular fluid.

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In periodontitis, an effective host-response is primarily related to neutrophils loaded with serine proteases, including elastase (NE) and protease 3 (PR3), the extracellular activity of which is tightly controlled by endogenous inhibitors. In vitro these inhibitors are degraded by gingipains,

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