Proprietary Botanical Blend - Dietary supplement with alpha amylase and sucrase inhibitory activity. 2 capsules

Non/minimally nutritive nonactive material: rice flour. 2 capsules

Hyperglycemia

Carbohydrate

Insulin Resistance

Malabsorption

Oral administration of capsules containing proprietary botanical blend 30 minutes prior to carbohydrate ingestion.

Proprietary Botanical Blend

Oral administration of capsules containing rice flour (placebo) 30 minutes prior to carbohydrate ingestion.

Placebo

Effect of Proprietary Botanical Blend on Glycemic Control and Post-prandial Carbohydrate Absorption

Effect of Proprietary Botanical Blend on Glycemic Control and Post-prandial Carbohydrate Absorption in Overweight, Insulin Resistant Adult Men and Women

Plasma glucose concentrations after the ingestion of a high carbohydrate meal

Measurement of hydrogen in exhaled air as an indicator of carbohydrate absorption

Plexus Worldwide

Participants will receive both treatments in random order with a washout period of at least 1 week between the 2 study visits. Women will be measured during the follicular phase of the menstrual cycle.

Treatment and placebo will be matched closely in color and appearance administered in a double blinded fashion as provided by the material supplier.

3g of cinnamon or placebo control were added to a test-meal.

Gastric Emptying

Diabetes Mellitus

acute oral administration of 3 g cinnamon

Cinnamon

3 g wheat flour (placebo)- separated by 28 days from cinnamon intervention

Placebo control

Department of Physical Education & Sport Sciences, University of Limerick

The Effect of Natural Food Flavourings on Gastrointestinal and Cardiovascular Physiological Responses.

Effect of Cinnamon on Gastric Emptying, Arterial Stiffness, Postprandial Lipaemia, Glycaemia, and Appetite Responses to High-fat Breakfast

Post-prandial changes in pulse wave velocity (m/s) will be measured non-invasively, using Pulsetrace PSA2 to indicate arterial stiffness.

Plasma concentration (mmol/l) of triacylglycerols, LDL, and HDL will be measured every hour in the post-prandial period.

The concentration of plasma glucose (mmol/l) will measured hourly in the postprandial period, using venous blood drawn from a forearm vein.

Subjective sensation of hunger, desire to eat, fullness, thirst, tiredness and coldness will be meaured using a 150mm visual analogue scale (mm).

Serum lipidhydroperoxides will be measured using FOX-1 assay.

A buffet meal will be presented to the volunteer 6h after breakfast. Food intake will be monitored covertly by weighing individiual food items before and after presentation. Food intake will be expressed as macronutrient (carbohydrate, fat, protein, water, fibre) and energy intake.

Amir Shafat, PhD

University of Limerick

University of Ulster

Ulster Hospital, Northern Ireland

National University of Ireland, Galway, Ireland

Subjects in this group will receive cinnamon capsules for 12 weeks period. The 2 g dose of cinnamon will be spread over the day as 500 mg (1 capsule) after breakfast, 1000 mg (2 capsules) after lunch and 500 mg (1 capsule) after dinner. The subjects will be instructed to take the capsules immediately after the meals.

Subjects in this group will receive placebo capsules (starch flour) for 12 weeks period. The 2 g dose of starch capsules will be spread over the day as 500 mg (1 capsule) after breakfast, 1000 mg (2 capsules) after lunch and 500 mg (1 capsule) after dinner. The subjects will be instructed to take the capsules immediately after the meals.

Type 2 Diabetes Mellitus

Subjects in intervention group will receive cinnamon capsules for 12 weeks period. The 2 g dose of cinnamon will be spread over the day as 500 mg (1 capsule) after breakfast, 1000 mg (2 capsules) after lunch and 500 mg (1 capsule) after dinner. The subjects will be instructed to take the capsules immediately after the meals.

cinnamon 2g per day for 12 weeks

Brent teaching Primary Care trust (NHS)

Is There a Metabolic Effect of Cinnamon on HbA1c, Blood Pressure and Serum Lipids in Type 2 Diabetes Mellitus?

The Effect of Dietary Supplementation of Cinnamon (Cinnamon Cassia) on HbA1c, Blood Pressure and Serum Lipid Measurements in Patients With Type 2 Diabetes Mellitus: a Randomised Placebo Controlled, Double Blind Clinical Trial

cinnamon/carbohydrate

Effect of Proprietary Botanical Blend on Glycemic Control and Post-prandial Carbohydrate Absorption

The Effect of Natural Food Flavourings on Gastrointestinal and Cardiovascular Physiological Responses.

Is There a Metabolic Effect of Cinnamon on HbA1c, Blood Pressure and Serum Lipids in Type 2 Diabetes Mellitus?

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