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COLchicine to Prevent Sympathetic Denervation After an Acute Myocardial Infarction

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COLD-MI study aims to explore colchicine's impact on myocardial denervation following reperfused acute myocardial infarction. Acute myocardial infarction is the leading cause of heart failure (HF). It induces myocardial denervation predisposing to ventricular rhythm disorders and death. This

Oral Colchicine in Argentina to Prevent Restenosis

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In a previous randomized comparison oral colchicine plus bare metal stent (BMS) compared to BMS plus placebo in a diabetic High risk for re-stenosis population, OC demonstrate a significant reduction of angiographic and intravascular ultrasound parameters of in-stent restenosis (ISR) after BMS

Repurposing Colchicine to Improve Vascular Function in Hypertension

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In this project w the potential beneficial effect of the drug colchicine on vascular reactivity and blood pressure is evaluated. Colchicine is a commonly used anti-inflammatory medication approved for the treatment of gout, Familial Mediterranean Fever and pericarditis in Denmark. The current

Effect of Colchicine in Patients With Myocardial Infarction

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Over the past years, a substantial volume of evidence has accumulated identifying inflammatory processes as key mediators of the deleterious effects of ischemia/reperfusion-related phenomena in patients presenting with ST-segment-elevation myocardial infarction (STEMI). Nevertheless, equally

Canadian Study of Arterial Inflammation in Patients With Diabetes and Vascular Events: EvaluatioN of Colchicine

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Inflammation is a key to atherosclerosis and its serious effects (MI, stroke) and represents a potentially transformative therapeutic target. Several recent trials have revealed potential outcome benefit in patients with cardiovascular disease who are treated with anti-inflammatory therapy. The

Colchicine Prevents Myocardial Injury After Non-Cardiac Surgery Pilot Study

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Perioperative Myocardial Infarction (PMI) is a major contributor to perioperative mortality and morbidity with overall incidence of 5-16% (1, 2). It is associated with increased 30-day mortality of 11.6% vs 2.2% of patients without PMI in non-cardiac surgical patients (1). However, its recognition

Colchicine in Periprocedural Myocardial Infarction: the Role of Alpha Defensin

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Clinical Trial to Evaluate the Efficacy of a Dyslipidemic Therapy in Mexican Population

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General objectives: Evaluate the therapeutic efficacy in Mexican adults with dyslipidemia through the oral route use of L-carnitine + atorvastatin in comparison with the use of Atorvastatin, after six months of treatment. Evaluate the safety of the medicines under study. Hypothesis: The combined use

COlchicine for Left VEntricular Remodeling Treatment in Acute Myocardial Infarction

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Colchicine and Spironolactone in Patients With STEMI / SYNERGY Stent Registry

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This is a multicenter, international SYNERGY Stent registry that is embedded within a randomized, blinded, double-dummy, 2x2 factorial design trial of colchicine versus placebo and spironolactone versus placebo in patients with ST-elevation myocardial infarction who have undergone primary

Mechanistic Effects of Colchicine in Patients With Myocardial Infarction

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This is a pilot study to explore the mechanistic effects of colchicine in patients with MI. The study will be conducted sequentially in 3 parts: 1. Blood will be collected from up to 10 healthy volunteers for protocol development. (Group 1). 2. Blood will be collected from 20 MI patients within 24

Colchicine for Prevention of Vascular Inflammation in Non-cardio Embolic Stroke

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Inflammation is a key pathophysiological contributor to unstable atherosclerotic plaque and thrombo-embolic events, stroke, myocardial infarction, and vascular death. Internationally, clinical trials are targeting atherosclerotic inflammation in patients with coronary disease using methotrexate,

Colchicine Cardiovascular Outcomes Trial (COLCOT)

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Atherosclerosis is the most common cause of myocardial infarction, stroke and peripheral arterial disease. Research has clearly demonstrated that inflammation plays a key role in the initiation, progression and manifestations of atherosclerosis. Atherosclerotic lesions begin as an accumulation of

Interest of COLchicine in the Treatment of Patients With Acute Myocardial INfarction and With Inflammatory Response

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Colchicine in Coronary Artery Bypass Graft (CABG)

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