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colchicine/inflamação
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6 resultados
Sustained-release formulations of colchicine and methods of using same
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BACKGROUND OF THE INVENTION
Colchicine, chemical name (-)-N-[(7S,12aS)-1,2,3,10-tetramethoxy-9-oxo-5,6,7,9-tetrahydrobenzo[a]he- ptalen-7-yl]-acetamide, is an alkaloid found in extracts of Colchicum autumnale, Gloriosa superba, and other plants. It is a microtubule-disrupting agent used in the
Sustained-release formulations of colchicine and methods of using same
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BACKGROUND OF THE INVENTION
Colchicine, chemical name (-)-N-[(7S, 12a5)-1,2,3,10-tetramethoxy-9-oxo-5,6,7,9-tetrahydrobenzo[a]heptalen-7-yl- ]-acetamide, is an alkaloid found in extracts of Colchicum autumnale, Gloriosa superba, and other plants. It is a microtubule-disrupting agent used in the
Method and composition for treating inflammatory disorders
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FIELD OF THE INVENTION
This invention relates to the treatment of certain diseases and disorders primarily, but not exclusively, in the field of human medicine and to compositions for use therein.
GENERAL BACKGROUND
Considerable interest has been shown in recent years in the use of prostaglandin
Tricyclic derivatives and their use
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FIELD OF THE INVENTION
The present invention relates to novel tricyclic colchicine derivatives represented by the formulas (I) or (II), or pharmaceutically acceptable salts thereof, and a method for providing an immuno-suppressive or immuno-modulating effect, an anti-proliferative effect, an
Allocolchinones and uses thereof
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BACKGROUND OF THE INVENTION
Colchicine (1) is an alkaloid having a tricyclic ring structure. A numbering system for the ring atoms and a lettering system for the three rings are indicated in (1). ##STR1##
Colchicine binds to the protein tubulin irreversibly. Tubulin is part of the cellular
Colchicoside analogues
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FIELD OF THE INVENTION
The present invention relates to colchicine derivatives, in particular 3-demethyl- and 3-demethylthio-colchicine derivatives with muscle relaxant, anti-inflammatory and anti-gout activity.
TECHNOLOGICAL BACKGROUND
Relaxant drugs reduce muscle tone and are used in therapy for
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