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Analysis of benzodiazepines and tricyclic antidepressants in serum using a common solid-phase clean-up and a common mobile phase.

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A single, rapid and specific solid-phase clean-up procedure was developed for the analysis of benzodiazepines and tricyclic antidepressants using a carefully selected wash step and specific sequential elution. Benzodiazepines were eluted from the solid-phase column using as mixture of

Contribution of common genetic variants to antidepressant response.

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BACKGROUND Pharmacogenetic studies aiming to personalize the treatment of depression are based on the assumption that response to antidepressants is a heritable trait, but there is no compelling evidence to support this. METHODS We estimate the contribution of common genetic variation to

Common mechanism of action of biochemically "specific" antidepressants.

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NE turnover in depressed patients treated with three drugs which have specifically different primary biochemical effects is compared before and after treatment. Turnover is quantitated as the sum of NE and its major metabolites excreted in the urine using a new mass spectrometric assay. Clorgyline ,

Ketamine and magnesium common pathway of antidepressant action.

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Depression is one of the major causes of disability worldwide. A proportion of adults with major depression fail to achieve remission with first-line treatment. Magnesium influences the neurotransmission involved in emotional processes, such as the serotonergic, noradrenergic, dopaminergic,

Do antidepressants possess a common mechanism of action?

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Management of common anxiety disorders.

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Anxiety disorders affect 16 percent of the U.S. population. Family physicians treat 90 percent of patients presenting with one or more anxiety disorders. Common anxiety disorders include generalized anxiety disorder, panic disorder and social phobia. Differentiation among these disorders may be

Common antidepressant treatment considerably increases risk of gastrointestinal bleeding.

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[Sexual dysfunction is common during treatment with antidepressive agents].

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Antidepressant Discontinuation Syndrome: A Common but Underappreciated Clinical Problem.

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Common mechanisms of pain and depression: are antidepressants also analgesics?

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Neither pain, nor depression exist as independent phenomena per se, they are highly subjective inner states, formed by our brain and built on the bases of our experiences, cognition and emotions. Chronic pain is associated with changes in brain physiology and anatomy. It has been suggested that the

Cytoprotective effect is one of common action pathways for antidepressants.

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OBJECTIVE To explore the possible common action mechanism of antidepressants. METHODS The cell viability was detected by MTT assay. The intracellular Ca2+ concentration ([Ca2+]i) was measured by Fura 2-AM fluorescence labeling assay. Using RT-PCR, the mRNA level of nerve growth factor (NGF) was also

Physical activity and common mental disorders.

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BACKGROUND Previous studies have suggested that physical activity may have antidepressant and/or anti-anxiety effects. OBJECTIVE To examine the bidirectional relationship between physical activity and common mental disorders and establish the importance of context, type and intensity of activity

Psychotic depression: the common therapeutic principle.

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Cholinergic prevalence together with a monaminergic deficit characterize the neurotransmitter imbalance underlying psychotic depression. Correction of this neurotransmitter imbalance is the principal purpose and goal of all treatment methods for the relief of psychotic depression. This can be

Common gastrointestinal symptoms: irritable bowel syndrome.

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The diagnosis of irritable bowel syndrome (IBS) should be considered when patients have had abdominal pain/discomfort, bloating, and change in bowel habits for 6 months. Patients may experience variation between periods of constipation and diarrhea. When evaluating patients with IBS, physicians

Common pathways of depression and pain.

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Depressive disorders are chronic conditions that produce both emotional and physical symptoms. Increasing evidence suggests that in some patients with depressive disorders a neurodegenerative process may occur, highlighting the importance of early and aggressive intervention. Serotonin (5-HT) and

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